Protein containing a scavenger receptor cysteine rich domain

ABSTRACT

The present invention relates to a protein containing an SRCR domain, a nucleic acid encoding such a protein and a method to produce same. The invention further relates to the use of the nucleic acid and the protein and antibodies directed against the protein.

The present invention relates to a protein containing an SRCR domain, anucleic acid encoding such a protein and a method to produce same. Inaddition, this invention concerns the use of the nucleic acid andprotein as well as antibodies directed against the protein.

The expression “SRCR” domain means “scavenger receptor cysteine rich”domain. Such a domain comprises about 110 amino acids and is found inmany proteins involved in elemental processes of the cell, e.g. celldifferentiation or cell-to-cell contact. Nevertheless, these processeshave not yet been understood in detail.

Therefore, it is the object of the present invention to provide aproduct by means of which it is possible to investigate, and optionallyinterfere with, elemental processes of the cells.

According to the invention this is achieved by the subject mattersdefined in the claims.

Therefore, the subject matter of the present invention relates to aprotein containing an SRCR domain, the protein comprising the amino acidsequence of FIG. 1 (SEQ ID NO:1) or an amino acid sequence differingtherefrom by one or several amino acids.

The present invention is based on the applicant's discovery that inanimals, particularly mammals, more particularly human beings, thereexists a protein containing an SRCR domain, which has homologies toknown proteins containing an SRCR domain but differing from theseproteins on the DNA level by hybridization under conventionalconditions. Such a protein comprises the amino acid sequence of FIG. 1(SEQ ID NO:1) or an amino acid sequence differing therefrom by one orseveral amino acids. In addition, the applicant recognized that theprotein also contains a CUB domain which also comprises about 110 aminoacids. Moreover, he found that the protein can be present in tumor cellsin a form other than that existing in normal cells. The modified formcan present itself as additions, substitutions, inversions and/ordeletions of one or several amino acids. In particular, the applicantfound that the protein may have a deletion of one or several amino acidsin medulloblastomas and glioblastomas and in the case of breast cancer.

The present invention refers to the above protein as “a proteincontaining an SRCR domain” (SRCR protein).

A further subject matter of the present invention relates to a nucleicacid coding for an (SRCR protein). It may be an RNA or a DNA. The lattermay be e.g. a genomic DNA or a cDNA. Preferred is a DNA which comprisesthe following:

(a) the DNA of FIG. 1 (SEQ ID NO:1) or a DNA differing therefrom by oneor several base pairs,

(b) a DNA hybridizing with the DNA from (a), or

(c) a DNA related to the DNA from (a) or (b) via the degenerated geneticcode.

The expression “hybridizing DNA” refers to a DNA which hybridizes with aDNA from (a) under normal conditions, particularly at 20° C. below themelting point of the DNA.

The DNA of FIG. 1 (SEQ ID NO:1) was deposited with the DSMZ (DeutscheSammlung von Mikroorganismen und Zellkulturen Gmbh, Mascheroder Weg 1b,D-38124 Braunschweig, Germany) as HFL2 under deposit accession numberDSM11281 on Nov. 8, 1996 under the Budapest Treaty on the InternationalRecognition of the Deposit of Microorganisms for the Purposes of PatentProcedure.

A nucleic acid according to the invention is described below in the formof a DNA, particularly cDNA. It is exemplary for every nucleic acid,particularly DNA, falling under the present invention.

For the production of a cDNA according to the invention it is favorableto use mRNA from human fetal lung as a basis. Such an mRNA is known, itcan be purchased e.g. from Clonetech. Full-length CDNA is generated fromthe mRNA, e.g. via oligodT-priming in combination with Cap-snatching. Aperson skilled in the art is familiar with the methods and conditions. AcDNA adapter, e.g. from the marathon kit from Clonetech, is ligated tothe full-length cDNA in a blunt-end fashion. Then, the cDNA is subjectedto a PCR method which uses primer pairs, one primer being specific tothe cDNA adapter and the other primer being specific to DNA sequencesfrom known proteins containing an SRCR domain. An example of the latterprimer is:

cubf1 5′-TGCACATCTCTGAAGACCACAG-3′  (SEQ ID NO:12)

in the 5′ direction, and

41nr1 5′-GTGGTCTGCAGGCAGCTG-3′  (SEQ ID NO:9)

in the 3′ direction.

The 41nr1 primer is localized in a strongly preserved or conservedregion of SRCR domains, the cubf1 primer is localized in a stronglypreserved region of CUB domains. In accordance with the primercombination, an amplified cDNA is obtained which was amplified in the 5′direction and 3′ direction, respectively. The amplified cDNA ishybridized with a labeled DNA probe specific to a nucleic acid accordingto the invention. Such DNA probes are e.g. the below DNA probesaime2e4f1 and a60kexf2:

DNA probe aime2e4f1: 5′-AGGCCAGATACTTGGCTGAC-3′  (SEQ ID NO:10)

DNA probe a60kexf2: 5′-CTTCAGATTACTGAAGCCCAGG-3′  (SEQ ID NO:11)

A cDNA which hybridizes with the DNA probe aime2e4f1 and was amplifiedin the 5′ direction, is ligated with a cDNA which was amplified in the3′ direction and hybridizes with the DNA probe a60kexf2. The ligationproduct is a cDNA according to the invention.

A cDNA according to the invention can be present in a vector andexpression vector, respectively. A person skilled in the art is familiarwith examples thereof. In the case of an expression vector for E. colithese are e.g. pGEMEX, pUC derivatives, pGEX-2T, pET3b and pQE-8, thelatter being preferred. For the expression in yeast e.g. pY100 andYcpad1 have to be mentioned, while e.g. pKCR, pEFBOS, cDM8 and pCEV4have to be indicated for the expression in animal cells. Thebacculovirus expression vector pAcSGHisNT-A is especially suitable forthe expression in insect cells.

The person skilled in the art is familiar with suitable cells to expressa cDNA according to the invention, which is present in an expressionvector. Examples of such cells comprise the E. coli strains HB101, DH1,x1776, JM101, JM109, BL21 and SG13009, the latter being preferred, theyeast strain saccharomyces cerevisiae and the animal cells L, 3T3, FM3A,CHO, COS, Vero and HeLa as well as the insect cells sf9.

The person skilled in the art knows in which way a DNA according to theinvention has to be inserted in an expression vector. He is alsofamiliar with the fact that this DNA can be inserted in combination witha DNA coding for another protein and peptide, respectively, so that thecDNA according to the invention can be expressed in the form of a fusionprotein.

In addition, the person skilled in the art knows conditions of culturingtransformed cells and transfected cells, respectively. He is alsofamiliar with processes of isolating and purifying the protein expressedby the cDNA according to the invention. Thus, such a protein, which mayalso be a fusion protein, is also a subject matter of the presentinvention.

A further subject matter of the present invention relates to an antibodydirected against an above protein and fusion protein, respectively. Suchan antibody can be prepared by common methods. It may be polyclonal andmonoclonal, respectively. For its preparation it is favorable toimmunize animals—particularly rabbits or chickens for a polyclonalantibody and mice for a monoclonal antibody—with an above (fusion)protein or with fragments thereof. Further “boosters” of the animals canbe effected with the same (fusion) protein or with fragments thereof.The polyclonal antibody may then be obtained from the animal serum andegg yolk, respectively. For the preparation of the monoclonal antibody,animal spleen cells are fused with myeloma cells.

The present invention enables to investigate elemental processes of thecell. By means of a nucleic acid according to the invention,particularly a DNA, and primers derived therefrom, it can be determinedin mammals, particularly human beings, whether they contain and/orexpress a gene which codes for an (SRCR protein). It can also bedetermined in which form the (SRCR protein) is present and whichsignificance the individual forms have for the cell and processesthereof, respectively. For example, the applicant discovered that inmedulloblastomas and glioblastomas as well as in breast cancer the (SRCRprotein) includes a deletion. This deletion can also be identified on agenomic level. The genomic DNA clones pBa112, pBa74, pBa36, pBa41,PG141BF17, PG141BA10, pBa60, pBa101 and pBa131 are provided which in thelisted order indicate a DNA range from 5′->3′ (cf. FIGS. 3, 4, and 5)which is present in normal cells but has deletions on both allels intumor cells, particularly in cells of a medulloblastoma, glioblastoma orbreast cancer. Said DNA clones also represent a subject matter of thepresent invention. They were also deposited with the DSMZ: pBa74 underDSM 11280, pBa36 under DSM 11272, pBa41 under DSM 11278 and pBa60 underDSM 11279, on Nov. 8, 1996 each; and PG141BF17 under DSM 11649,PG141BA10 under DSM 11648, pBa101 under DSM 11646 and pBa131 under DSM11647, on Jul. 4, 1997 each. In addition to the coding sequence thegenomic clones provide intron sequences. They are suitable for mutationanalysis in tumors, e.g. as hybridization probes or with primers derivedtherefrom. The genomic clones thus provide diagnostic agents. Forcarrying out the above investigations conventional methods such asreverse transcription, PCR reaction, hybridization and sequencing can beused. According to the invention a kit is also provided which containsan above nucleic acid, particularly DNA, and/or primers derivedtherefrom as well as carriers and conventional auxiliary agents.Moreover, diagnostic steps can be taken with an (SRCR protein) accordingto the invention. In particular, it can be determined whetherautoantibodies exist against such a protein.

Furthermore, the present invention is suitable to interfere withelemental processes of the cell. An (SRCR protein) can be inserted inmammals, particularly human beings. For this purpose, it may befavorable to couple the (SRCR protein) to a protein which is notconsidered foreign by the respective body, e.g. transferrin or BSA. Anucleic acid according to the invention, particularly a DNA, can also beinserted and expressed in mammals, particularly human beings. For thispurpose, it may be favorable to control the expression of the nucleicacid according to the invention by a tissue-specific promoter. Theexpression of an (SRCR protein) can be controlled and regulated by anantibody according to the invention.

Thus, the present invention represents a great contribution to thediagnostic and therapeutic detection of elemental processes of the cell.In particular, tumoral diseases, particularly of the central nervoussystem, e.g. medulloblastomas or glioblastomas, as well as the breastcan be diagnosed on a genetic level and steps can be taken thereagainst.The diagnostic detection of elemental processes of the cell cannot onlybe made postnatally but also already prenatally in this connection.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the base sequence (SEQ ID NO:1) and the amino acid sequence(SEQ ID NO:2), derived therefrom, of an (SRCR protein) according to theinvention,

FIG. 2 shows the base sequence (SEQ ID NO:3) and the amino acid sequence(SEQ ID NO:4) derived therefrom, comprised by an (SRCR protein)according to the invention, the above FIG. 1 representing a section ofFIG. 2 (nucleotides 2958 to 4957),

FIG. 3 shows the restriction map and the relation of the genomic clonespBA74, pBa36, pBa41, PG141BF17, PG141BA10, pBa60, pBa101 and pBa131 withrespect to one another,

FIG. 4 shows the restriction map and the relation of the genomic clonespBa112, pBA74, pBa36, pBa41, PG141BF17, PG141BA10, pBa60, pBa101 andpBa131 with respect to one another. Furthermore, the sequence rangesSC1, SC2, SC3 and SC4 comprised by these clones are indicated, and

FIG. 5 shows the sequence of sequence ranges SC1 (SEQ ID NO:5), SC2 (SEQID NO:6), SC3 (SEQ ID NO:7) and SC4 (SEQ ID NO:8) (FIGS. 5(a), (b), (c),(d)). Furthermore, a range is marked in SC4 by underlining, which codesfor a transmembrane domain.

The present invention is explained by the below examples.

EXAMPLE 1

Preparation and Purification of an (SRCR Protein) According to theInvention

For preparing an (SRCR protein) according to the invention, an mRNA fromhuman fetal lung (Clonetech) was used. Full-length cDNA was preparedfrom the mRNA, oligodT priming being carried out in combination with“Cap snatching”. A cDNA adapter from the marathon kit from Clonetech wasligated to the full-length cDNA in blunt-end fashion. The cDNA was thensubjected to a PCR method. The primer pairs used were:

cubf1 5′-TGCACATCTCTGAAGACCACAG-3′  (SEQ ID NO:12)

in the 5′ direction and

41nr1 5′-GTGGTCTGCAGGCAGCTG-3′  (SEQ ID NO:9)

in the 3′ direction, respectively, each in combination with a primerspecific to the cDNA adapter.

The PCR batch and PCR conditions were as follows:

PCR Batch

Template DNA: 1 μl=10 ng

10×TaKARa long-range PCR buffer: 2.5 μl

MgCl₂ (25 mM): 2.5 μl

Taq/Pfu polymerase mix (19:1): 0.25 μl

dNTP mix (10 mM each): 1 μl

oligonucleotides (10 pmol/μl): 1 μl

H₂O bidist.: ad 25 μl

PCR Conditions

95° C.  3 min. 1 cycle 94° C. 15 sec. 60° C. 10 sec. 68° C.  4 min. 15cycles 94° C. 15 sec. 60° C. 10 sec. 68° C.  4 min. 10 cycles having anextension of 10 sec. of the 68° C. step each per cycle

The amplified cDNA was subjected to hybridization with theabove-indicated DNA probes aime2e4f1 and a60kexf2. Their sequences arespecific to the above-mentioned genomic DNA clone pBa60. cDNA wasidentified which hybridized with the DNA probes. This cDNA had beenamplified in the 5′ direction and 3′ direction, respectively. The cDNAwas purified over an agarose gel electrophoresis and cleaved by SwaI.After another agarose gel electrophoresis, a cDNA amplified in the 5′direction was ligated with one amplified in the 3′ direction. Theligation product was sequenced. It comprised the DNA of FIG. 1. Theligation product was cleaved by NotI and inserted in the expressionvector pQE-30 NST (Quiagen company) cleaved by NotI. The expressionplasmid pQ/SRCR protein was obtained. Such a protein codes for a fusionprotein from 6 histidine residues (N terminus partner) and an (SRCRprotein) according to the invention (C terminus partner). pQ/SRCRprotein was used for the transformation of E. coli SG 13009 (cf.Gottesman, S. et al., J. bacteriol. 148 (1981), 265-273). The bacteriawere cultured in an LB broth with 100 μg/ml ampicillin and 25 μg/mlkanamycin and induced with 60 μM isopropyl-β-D-thiogalactopyranoside(IPTG) for 4 h. By the addition of 6 M guanidine hydrochloride, lysis ofthe bacteria was achieved, then a chromatography (Ni-NTA resin) wascarried out with the lysate in the presence of 8 M urea in accordancewith the instructions from the manufacturer (Diagen company) of thechromatography material. The bound fusion protein was eluted in a bufferhaving a pH of 3.5. After its neutralization, the fusion protein wassubjected to 18% SDS polyacrylamide gel electrophoresis and stainedusing coomassie blue (cf. Thomas, J. O. and Kornberg, R. D., J. Mol.Biol. 149 (1975), 709-733).

It showed that a (fusion) protein according to the invention can beprepared in highly pure form.

EXAMPLE 2

Preparation and Detection of an Antibody According to the Invention

A fusion protein of Example 1 according to the invention was subjectedto 18% SDS polyacrylamide gel electrophoresis. After staining the gelwith 4 M sodium acetate, an about 260 kD band was cut out of the gel andincubated in phosphate-buffered common salt solution. Gel pieces weresedimented before the protein concentration of the supernatant wasdetermined by SDS polyacrylamide gel electrophoresis which was followedby coomassie blue staining. Animals were immunized with the gel-purifiedfusion protein as follows:

Immunization Protocol For Polyclonal Antibodies in Rabbits

35 μg of gel-purified fusion protein in 0.7 ml PBS and 0.7 ml ofcomplete Freund's adjuvant and incomplete Freund's adjuvant,respectively, were used per immunization:

Day 0: 1^(st) immunization (complete Freund's adjuvant)

Day 14: 2^(nd) immunization (incomplete Freund's adjuvant; icFA)

Day 28: 3^(rd) immunization (icFA)

Day 56: 4^(th) immunization (icFA)

Day 80: bleeding to death.

The rabbit serum was tested in an immunoblot. For this purpose, a fusionprotein of Example 1 according to the invention was subjected to SDSpolyacrylamide gel electrophoresis and transferred to a nitrocellulosefilter (cf. Khyse-Andersen, J., J. Biochem. Biophys. Meth. 10 (1984),203-209). The Western blot analysis was carried out as described inBock, C.-T. et al., Virus Genes 8, (1994), 215-229. For this purpose,the nitrocellulose filter was incubated with a first antibody at 37° C.for one hour. This antibody was the rabbit serum (1:10000 in PBS). Afterseveral wash steps using PBS, the nitrocellulose filter was incubatedwith a second antibody. This antibody was an alkalinephosphatase-coupled monoclonal goat anti-rabbit IgG antibody (Dianovacompany) (1:5000) in PBS. 30 minutes of incubation at 37° C. werefollowed by several wash steps using PBS and subsequently by thealkaline phosphatase detection reaction with developer solution (36 μM5′-bromo-4-chloro-3-indolylphosphate, 400 μM nitro blue tetrazolium, 100mM Tris-HCl, pH 9.5, 100 mM NaCl, 5 mM MgCl₂) at room temperature untilbands were visible.

It showed that polyclonal antibodies according to the invention can beprepared.

Immunization Protocol For Polyclonal Antibodies in Chickens

40 μg of gel-purified fusion protein in 0.8 ml PBS and 0.8 ml ofcomplete Freund's adjuvant and incomplete Freund's adjuvant,respectively, were used per immunization.

Day 0: 1^(st) immunization (complete Freund's adjuvant)

Day 28: 2^(nd) immunization (incomplete Freund's adjuvant; icFA)

Day 50: 3^(rd) immunization (icFA)

Antibodies were extracted from egg yolk and tested in a Western blot.Polyclonal antibodies according to the invention were detected.

Immunization Protocol For Monoclonal Antibodies in Mice

12 μg of gel-purified fusion protein in 0.25 ml PBS and 0.25 ml ofcomplete Freund's adjuvant and incomplete Freund's adjuvant,respectively, were used per immunization. The fusion protein wasdissolved in 0.5 ml (without adjuvant) in the 4^(th) immunization.

Day 0: 1^(st) immunization (complete Freund's adjuvant)

Day 28: 2^(nd) immunization (incomplete Freund's adjuvant; icFA)

Day 56: 3^(rd) immunization (icFA)

Day 84: 4^(th) immunization (PBS)

Day 87: fusion.

Supernatants of hybridomas were tested in a Western blot. Monoclonalantibodies according to the invention were detected.

SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 12 <210> SEQ ID NO 1 <211>LENGTH: 666 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:1 Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser 1 5 1015 His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 20 2530 Gln Ser Gln Ser Thr Pro Arg Pro Asp Thr Trp Leu Thr Thr Asn Leu 35 4045 Pro Ala Leu Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val 50 5560 Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly 65 7075 80 Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 8590 95 Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly100 105 110 Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp AspVal 115 120 125 Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro HisLys Gly 130 135 140 Trp Leu Thr His Asn Cys Gly His His Glu Asp Ala GlyVal Ile Cys 145 150 155 160 Ser Ala Thr Gln Ile Asn Ser Thr Thr Thr AspTrp Trp His Pro Thr 165 170 175 Thr Thr Thr Thr Ala Arg Pro Ser Ser AsnCys Gly Gly Phe Leu Phe 180 185 190 Tyr Ala Ser Gly Thr Phe Ser Ser ProSer Tyr Pro Ala Tyr Tyr Pro 195 200 205 Asn Asn Ala Lys Cys Val Trp GluIle Glu Val Asn Ser Gly Tyr Arg 210 215 220 Ile Asn Leu Gly Phe Ser AsnLeu Lys Leu Glu Ala His His Asn Cys 225 230 235 240 Ser Phe Asp Tyr ValGlu Ile Phe Asp Gly Ser Leu Asn Ser Ser Leu 245 250 255 Leu Leu Gly LysIle Cys Asn Asp Thr Arg Gln Ile Phe Thr Ser Ser 260 265 270 Tyr Asn ArgMet Thr Ile His Phe Arg Ser Asp Ile Ser Phe Gln Asn 275 280 285 Thr GlyPhe Leu Ala Trp Tyr Asn Ser Phe Pro Ser Asp Ala Thr Leu 290 295 300 ArgLeu Val Asn Leu Asn Ser Ser Tyr Gly Leu Cys Ala Gly Arg Val 305 310 315320 Glu Ile Tyr His Gly Gly Thr Trp Gly Thr Val Cys Asp Asp Ser Trp 325330 335 Thr Ile Gln Glu Ala Glu Val Val Cys Arg Gln Leu Gly Cys Gly Arg340 345 350 Ala Val Ser Ala Leu Gly Asn Ala Tyr Phe Gly Ser Gly Ser GlyPro 355 360 365 Ile Thr Leu Asp Asp Val Glu Cys Ser Gly Thr Glu Ser ThrLeu Trp 370 375 380 Gln Cys Arg Asn Arg Gly Trp Phe Ser His Asn Cys AsnHis Arg Glu 385 390 395 400 Asp Ala Gly Val Ile Cys Ser Gly Asn His LeuSer Thr Pro Ala Pro 405 410 415 Phe Leu Asn Ile Thr Arg Pro Asn Thr AspTyr Ser Cys Gly Gly Phe 420 425 430 Leu Ser Gln Pro Ser Gly Asp Phe SerSer Pro Phe Tyr Pro Gly Asn 435 440 445 Tyr Pro Asn Asn Ala Lys Cys ValTrp Asp Ile Glu Val Gln Asn Asn 450 455 460 Tyr Arg Val Thr Val Ile PheArg Asp Val Gln Leu Glu Gly Gly Cys 465 470 475 480 Asn Tyr Asp Tyr IleGlu Val Phe Asp Gly Pro Tyr Arg Ser Ser Pro 485 490 495 Leu Ile Ala ArgVal Cys Asp Gly Ala Arg Gly Ser Phe Thr Ser Ser 500 505 510 Ser Asn PheMet Ser Ile Arg Phe Ile Ser Asp His Ser Ile Thr Arg 515 520 525 Arg GlyPhe Arg Ala Glu Tyr Tyr Ser Ser Pro Ser Asn Asp Ser Thr 530 535 540 AsnLeu Leu Cys Leu Pro Asn His Met Gln Ala Ser Val Ser Arg Ser 545 550 555560 Tyr Leu Gln Ser Leu Gly Phe Ser Ala Ser Asp Leu Val Ile Ser Thr 565570 575 Trp Asn Gly Tyr Tyr Glu Cys Arg Pro Gln Ile Thr Pro Asn Leu Val580 585 590 Ile Phe Thr Ile Pro Tyr Ser Gly Cys Gly Thr Phe Lys Gln AlaAsp 595 600 605 Asn Asp Thr Ile Asp Tyr Ser Asn Phe Leu Thr Ala Ala ValSer Gly 610 615 620 Gly Ile Ile Lys Arg Arg Thr Asp Leu Arg Ile His ValSer Cys Arg 625 630 635 640 Met Leu Gln Asn Thr Trp Val Asp Thr Met TyrIle Ala Asn Asp Thr 645 650 655 Ile His Val Ala Asn Asn Thr Ile Gln Val660 665 <210> SEQ ID NO 2 <211> LENGTH: 2001 <212> TYPE: DNA <213>ORGANISM: Homo sapiens <400> SEQUENCE: 2 ggacacgagt cttawabcctgtggagctgc ccccacaatg gctggctctc ccacaactgt 60 ggccatcatg aagatgctggtgtcatctgc tcagctgctc agtcccagtc aacgcccagg 120 ccagatactt ggctgaccaccaacttaccg gcattgacag taggatctga atccagtttg 180 gctctgaggc tggtgaatggaggtgacagg tgtcgaggcc gagtggaggt cctgtatcga 240 ggctcctggg gaaccgtgtgtgatgacagc tgggacacca atgatgccaa tgtggtctgc 300 aggcagctgg gctgtggctgggccatgtcg gccccaggaa atgcccggtt tggccagggc 360 tcaggaccca ttgtcctggatgatgtgcgc tgctcaggga atgagtccta cctgtggagc 420 tgcccccaca aaggctggctcacccacaac tgtggccatc acgaagacgc tggtgtcatc 480 tgctcagcca cccaaataaattctactacg acagattggt ggcatccaac aactacaacc 540 actgcaagac cctcttcaaattgtggtggc ttcttattct atgccagtgg gacattctcc 600 agcccatcct accctgcatactaccccaac aatgctaagt gtgtttggga aatagaagtg 660 aattctggtt atcgcataaacctgggcttc agtaatctga aattggaggc acaccataac 720 tgcagttttg attatgttgaaatctttgat ggatcattga atagcagtct cctgctgggg 780 aaaatctgta atgataccaggcaaatattt acatcttctt acaaccgaat gaccattcac 840 tttcgaagtg acatcagtttccaaaacact ggctttttgg cttggtataa ctccttccca 900 agcgatgcca ccttgaggttggtcaattta aattcatcct atggtctatg tgccgggcgt 960 gtagaaattt accatggtggcacctggggg acagtttgtg atgactcctg gaccattcag 1020 gaagctgagg tggtctgcagacagctaggg tgtggacgtg cagtttcagc ccttggaaat 1080 gcatattttg gctctggctctggccccatc accctggacg atgtagagtg ctcagggacg 1140 gaatccactc tctggcagtgccggaaccga ggctggttct cccacaactg taatcatcgt 1200 gaagatgctg gtgtcatctgctcaggaaac catctatcga cacctgctcc ttttctcaac 1260 atcacccgtc caaacacagattattcctgc ggaggcttcc tatcccaacc atcaggggac 1320 ttttccagcc cattctatcccgggaactat ccaaacaatg ccaagtgtgt gtgggacatt 1380 gaggtgcaaa acaactaccgtgtgactgtg atcttcagag atgtccagct tgaaggtggc 1440 tgcaactatg attatattgaagttttcgat ggcccctacc gcagttcccc tctcattgct 1500 cgagtttgtg atggggccagaggctccttc acttcttcct ccaacttcat gtccattcgc 1560 ttcatcagtg accacagcatcacaaggaga gggttccggg ctgagtacta ctccagtccc 1620 tccaatgaca gcaccaacctgctctgtctg ccaaatcaca tgcaagccag tgtgagcagg 1680 agctatctcc aatccttgggcttttctgcc agtgaccttg tcatttccac ctggaatgga 1740 tactacgagt gtcggccccagataacgccg aacctggtga tattcacaat tccctactca 1800 ggctgcggca ccttcaagcaggcagacaat gacaccatcg actattccaa cttcctcaca 1860 gcagctgtct caggtggcatcatcaagagg aggacagacc tccgtattca cgtcagctgc 1920 agaatgcttc agaacacctgggtcgacacc atgtacattg ctaatgacac catccacgtt 1980 gctaataaca ccatccaggt c2001 <210> SEQ ID NO 3 <211> LENGTH: 1785 <212> TYPE: PRT <213>ORGANISM: Homo sapiens <400> SEQUENCE: 3 Met Gly Ile Ser Thr Val Ile LeuGlu Met Cys Leu Leu Trp Gly Gln 1 5 10 15 Val Leu Ser Thr Gly Gly TrpIle Pro Arg Thr Thr Asp Tyr Ala Ser 20 25 30 Leu Ile Pro Ser Glu Val ProLeu Asp Gln Thr Val Ala Glu Gly Ser 35 40 45 Pro Phe Pro Ser Glu Ser ThrLeu Glu Ser Thr Ala Ala Glu Gly Ser 50 55 60 Pro Ile Ser Leu Glu Ser ThrLeu Glu Ser Thr Val Ala Glu Gly Ser 65 70 75 80 Leu Ile Pro Ser Glu SerThr Leu Glu Ser Thr Val Ala Glu Gly Ser 85 90 95 Asp Ser Gly Leu Ala LeuArg Leu Val Asn Gly Asp Gly Arg Cys Gln 100 105 110 Gly Arg Val Glu IleLeu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 115 120 125 Asp Ser Trp AspThr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 130 135 140 Cys Gly TrpAla Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 145 150 155 160 SerGly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 165 170 175Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 180 185190 His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 195200 205 Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro210 215 220 Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn GlyGly 225 230 235 240 Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg GlySer Trp Gly 245 250 255 Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp AlaAsn Val Val Cys 260 265 270 Arg Gln Leu Gly Cys Gly Trp Ala Met Ser AlaPro Gly Asn Ala Gln 275 280 285 Phe Gly Gln Gly Ser Gly Pro Ile Val LeuAsp Asp Val Arg Cys Ser 290 295 300 Gly His Glu Ser Tyr Leu Trp Ser CysPro His Asn Gly Trp Leu Thr 305 310 315 320 His Asn Cys Gly His Ser GluAsp Ala Gly Val Ile Cys Ser Ala Pro 325 330 335 Gln Ser Arg Pro Thr ProSer Pro Asp Thr Trp Pro Thr Ser His Ala 340 345 350 Ser Thr Ala Gly ProGlu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 355 360 365 Gly Asp Arg CysGln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 370 375 380 Gly Thr ValCys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 385 390 395 400 CysArg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 405 410 415Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 420 425430 Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 435440 445 Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala450 455 460 Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr IleThr 465 470 475 480 Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu AlaLeu Arg Leu 485 490 495 Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val GluVal Leu Tyr Gln 500 505 510 Gly Ser Trp Gly Thr Val Cys Asp Asp Ser TrpAsp Thr Asn Asp Ala 515 520 525 Asn Val Val Cys Arg Gln Pro Gly Cys GlyTrp Ala Met Ser Ala Pro 530 535 540 Gly Asn Ala Arg Phe Gly Gln Gly SerGly Pro Ile Val Leu Asp Asp 545 550 555 560 Val Arg Cys Ser Gly His GluSer Tyr Pro Trp Ser Cys Pro His Asn 565 570 575 Gly Trp Leu Ser His AsnCys Gly His Ser Glu Asp Ala Gly Val Ile 580 585 590 Cys Ser Ala Ser GlnSer Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro 595 600 605 Thr Ser His AlaSer Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu Arg 610 615 620 Leu Val AsnGly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr 625 630 635 640 ArgGly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp 645 650 655Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala 660 665670 Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp 675680 685 Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His690 695 700 Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala GlyVal 705 710 715 720 Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser ProAsp Thr Trp 725 730 735 Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu SerSer Leu Ala Leu 740 745 750 Arg Leu Val Asn Gly Gly Asp Arg Cys Gln GlyArg Val Glu Val Leu 755 760 765 Tyr Arg Gly Ser Trp Gly Thr Val Cys AspAsp Tyr Trp Asp Thr Asn 770 775 780 Asp Ala Asn Val Val Cys Arg Gln LeuGly Cys Gly Trp Ala Thr Ser 785 790 795 800 Ala Pro Gly Asn Ala Arg PheGly Gln Gly Ser Gly Pro Ile Val Leu 805 810 815 Asp Asp Val Arg Cys SerGly His Glu Ser Tyr Leu Trp Ser Cys Pro 820 825 830 His Asn Gly Trp LeuSer His Asn Cys Gly His His Glu Asp Ala Gly 835 840 845 Val Ile Cys SerAla Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr 850 855 860 Trp Pro ThrSer Arg Ala Ser Thr Ala Gly Ser Glu Ser Thr Leu Ala 865 870 875 880 LeuArg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Val 885 890 895Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr 900 905910 Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met 915920 925 Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly Ser Gly Pro Ile Val930 935 940 Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp SerCys 945 950 955 960 Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His HisGlu Asp Ala 965 970 975 Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser ThrPro Arg Pro Asp 980 985 990 Thr Trp Leu Thr Thr Asn Leu Pro Ala Leu ThrVal Gly Ser Glu Ser 995 1000 1005 Ser Leu Ala Leu Arg Leu Val Asn GlyGly Asp Arg Cys Arg Gly Arg 1010 1015 1020 Val Glu Val Leu Tyr Arg GlySer Trp Gly Thr Val Cys Asp Asp Ser 1025 1030 1035 1040 Trp Asp Thr AsnAsp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 1045 1050 1055 Trp AlaMet Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 1060 1065 1070Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu 10751080 1085 Trp Ser Cys Pro His Lys Gly Trp Leu Thr His Asn Cys Gly HisHis 1090 1095 1100 Glu Asp Ala Gly Val Ile Cys Ser Ala Thr Gln Ile AsnSer Thr Thr 1105 1110 1115 1120 Thr Asp Trp Trp His Pro Thr Thr Thr ThrThr Ala Arg Pro Ser Ser 1125 1130 1135 Asn Cys Gly Gly Phe Leu Phe TyrAla Ser Gly Thr Phe Ser Ser Pro 1140 1145 1150 Ser Tyr Pro Ala Tyr TyrPro Asn Asn Ala Lys Cys Val Trp Glu Ile 1155 1160 1165 Glu Val Asn SerGly Tyr Arg Ile Asn Leu Gly Phe Ser Asn Leu Lys 1170 1175 1180 Leu GluAla His His Asn Cys Ser Phe Asp Tyr Val Glu Ile Phe Asp 1185 1190 11951200 Gly Ser Leu Asn Ser Ser Leu Leu Leu Gly Lys Ile Cys Asn Asp Thr1205 1210 1215 Arg Gln Ile Phe Thr Ser Ser Tyr Asn Arg Met Thr Ile HisPhe Arg 1220 1225 1230 Ser Asp Ile Ser Phe Gln Asn Thr Gly Phe Leu AlaTrp Tyr Asn Ser 1235 1240 1245 Phe Pro Ser Asp Ala Thr Leu Arg Leu ValAsn Leu Asn Ser Ser Tyr 1250 1255 1260 Gly Leu Cys Ala Gly Arg Val GluIle Tyr His Gly Gly Thr Trp Gly 1265 1270 1275 1280 Thr Val Cys Asp AspSer Trp Thr Ile Gln Glu Ala Glu Val Val Cys 1285 1290 1295 Arg Gln LeuGly Cys Gly Arg Ala Val Ser Ala Leu Gly Asn Ala Tyr 1300 1305 1310 PheGly Ser Gly Ser Gly Pro Ile Thr Leu Asp Asp Val Glu Cys Ser 1315 13201325 Gly Thr Glu Ser Thr Leu Trp Gln Cys Arg Asn Arg Gly Trp Phe Ser1330 1335 1340 His Asn Cys Asn His Arg Glu Asp Ala Gly Val Ile Cys SerGly Asn 1345 1350 1355 1360 His Leu Ser Thr Pro Ala Pro Phe Leu Asn IleThr Arg Pro Asn Thr 1365 1370 1375 Asp Tyr Ser Cys Gly Gly Phe Leu SerGln Pro Ser Gly Asp Phe Ser 1380 1385 1390 Ser Pro Phe Tyr Pro Gly AsnTyr Pro Asn Asn Ala Lys Cys Val Trp 1395 1400 1405 Asp Ile Glu Val GlnAsn Asn Tyr Arg Val Thr Val Ile Phe Arg Asp 1410 1415 1420 Val Gln LeuGlu Gly Gly Cys Asn Tyr Asp Tyr Ile Glu Val Phe Asp 1425 1430 1435 1440Gly Pro Tyr Arg Ser Ser Pro Leu Ile Ala Arg Val Cys Asp Gly Ala 14451450 1455 Arg Gly Ser Phe Thr Ser Ser Ser Asn Phe Met Ser Ile Arg PheIle 1460 1465 1470 Ser Asp His Ser Ile Thr Arg Arg Gly Phe Arg Ala GluTyr Tyr Ser 1475 1480 1485 Ser Pro Ser Asn Asp Ser Thr Asn Leu Leu CysLeu Pro Asn His Met 1490 1495 1500 Gln Ala Ser Val Ser Arg Ser Tyr LeuGln Ser Leu Gly Phe Ser Ala 1505 1510 1515 1520 Ser Asp Leu Val Ile SerThr Trp Asn Gly Tyr Tyr Glu Cys Arg Pro 1525 1530 1535 Gln Ile Thr ProAsn Leu Val Ile Phe Thr Ile Pro Tyr Ser Gly Cys 1540 1545 1550 Gly ThrPhe Lys Gln Ala Asp Asn Asp Thr Ile Asp Tyr Ser Asn Phe 1555 1560 1565Leu Thr Ala Ala Val Ser Gly Gly Ile Ile Lys Arg Arg Thr Asp Leu 15701575 1580 Arg Ile His Val Ser Cys Arg Met Leu Gln Asn Thr Trp Val AspThr 1585 1590 1595 1600 Met Tyr Ile Ala Asn Asp Thr Ile His Val Ala AsnAsn Thr Ile Gln 1605 1610 1615 Val Glu Glu Val Gln Tyr Gly Asn Phe AspVal Asn Ile Ser Phe Tyr 1620 1625 1630 Thr Ser Ser Ser Phe Leu Tyr ProVal Thr Ser Arg Pro Tyr Tyr Val 1635 1640 1645 Asp Leu Asn Gln Asp LeuTyr Val Gln Ala Glu Ile Leu His Ser Asp 1650 1655 1660 Ala Val Leu ThrLeu Phe Val Asp Thr Cys Val Ala Ser Pro Tyr Ser 1665 1670 1675 1680 AsnAsp Phe Thr Ser Leu Thr Tyr Asp Leu Ile Arg Ser Gly Cys Val 1685 16901695 Arg Asp Asp Thr Tyr Gly Pro Tyr Ser Ser Pro Ser Leu Arg Ile Ala1700 1705 1710 Arg Phe Arg Phe Arg Ala Phe His Phe Leu Asn Arg Phe ProSer Val 1715 1720 1725 Tyr Leu Arg Cys Lys Met Val Val Cys Arg Ala TyrAsp Pro Ser Ser 1730 1735 1740 Arg Cys Tyr Arg Gly Cys Val Leu Arg SerLys Arg Asp Val Gly Ser 1745 1750 1755 1760 Tyr Gln Glu Lys Val Asp ValVal Leu Gly Pro Ile Gln Leu Gln Thr 1765 1770 1775 Pro Pro Arg Arg GluGlu Glu Pro Arg 1780 1785 <210> SEQ ID NO 4 <211> LENGTH: 5802 <212>TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 4 tttatagcagcagcagaaat ataccaccct agaggacaca cctcctttta gctaggtacc 60 tataaatgtccaggattttc tattcaattg agaagaaccc agcaaaatgg ggatctccac 120 agtcatccttgaaatgtgtc ttttatgggg acaagttcta tctacaggtg ggtggatccc 180 aaggactacagactacgctt cactgattcc ctcggaggtg cccttggatc aaactgtagc 240 agaaggttctccatttccct cggagtcgac cctggagtca actgcagcag aaggttctcc 300 gatttccttggagtcaaccc tggagtcaac tgtagcagaa ggttctctga ttccctcaga 360 gtcaaccctggagtcaactg tagcagaagg atctgattct ggtttggccc tgaggctggt 420 gaatggagatggcaggtgtc agggccgagt ggagatccta taccgaggct cctggggcac 480 cgtgtgtgatgacagctggg acaccaatga tgccaacgtg gtctgtaggc agctgggttg 540 tggctgggccatgtcagctc caggaaatgc ctggtttggc cagggctcag gacccattgc 600 cctggatgatgtgcgctgct caggacacga atcctacctg tggagctgcc cccacaatgg 660 ctggctctcccataactgtg gccatggtga agatgctggt gttatctgct cagctgccca 720 gcctcagtcaacactcaggc cagaaagttg gcctgtcagg atatcaccac ctgtacccac 780 agaaggatctgaatccagtt tggccctgag gctggtgaat ggaggcgaca ggtgtcgagg 840 ccgagtggaggtcctatacc gaggctcctg gggcaccgtg tgtgatgact actgggacac 900 caatgatgccaatgtggtct gcaggcagct gggctgtggc tgggccatgt cagccccagg 960 aaatgcccagtttggccagg gctcaggacc cattgtcctg gatgatgtgc gctgctcagg 1020 acacgagtcctacctgtgga gctgccccca caatggctgg ctcacccaca actgtggcca 1080 tagtgaagacgctggtgtca tctgctcagc tccccagtcc cggccgacac ccagcccaga 1140 tacttggccgacctcacatg catcaacagc aggacctgaa tccagtttgg ccctgaggct 1200 ggtgaatggaggtgacaggt gtcagggccg agtggaggtc ctataccgag gctcctgggg 1260 caccgtgtgtgatgatagct gggacaccag tgacgccaat gtggtctgcc ggcagctggg 1320 ctgtggctgggccacgtcag ccccaggaaa tgcccggttt ggccagggtt caggacccat 1380 tgtcctggatgacgtgcgct gctcaggcta tgagtcctac ctgtggagct gcccccacaa 1440 tggctggctctcccataact gtcagcacag tgaagacgct ggtgtcatct gctcagctgc 1500 ccactcctggtcgacgccca gtccagacac attgccgacc atcaccttgc ctgcatcgac 1560 agtaggatctgaatccagtt tggccctgag gctggtgaat ggaggtgaca ggtgtcaggg 1620 ccgagtggaggtcctatacc aaggctcctg gggcaccgtg tgcgatgaca gctgggacac 1680 caatgatgccaatgtcgtct gcaggcaacc gggctgtggc tgggccatgt cagccccagg 1740 aaatgcccggtttggtcagg gctcaggacc cattgtcctg gatgatgtgc gctgctcagg 1800 acacgagtcttacccgtgga gctgccccca caatggctgg ctctcccaca actgtggcca 1860 tagtgaagacgctggtgtca tctgctcagc ttcccagtcc cggccaacac ctagtccaga 1920 cacttggccaacctcacatg catcaacagc aggatctgaa tccagtttgg ccctgaggct 1980 ggtgaatggaggtgacaggt gtcagggccg agtggaggtc ctataccgag gctcctgggg 2040 caccgtgtgtgatgactact gggacaccaa tgatgccaat gtggtttgca ggcagctggg 2100 ctgtggctgggccatgtcag ccccaggaaa tgcccggttt ggccagggtt caggacccat 2160 tgtcctggatgatgtgcgct gctcaggaca tgagtcctat ctgtggagct gcccccacaa 2220 tggctggctctcccacaact gtggccatca tgaagacgct ggtgtcatct gctcagcttc 2280 ccagtcccagccgacaccca gcccagacac ttggccaacc tcacatgcat caacagcagg 2340 atctgaatccagtttggccc tgaggctggt gaatggaggt gacaggtgtc agggccgagt 2400 ggaggtcctataccgaggct cctggggcac cgtgtgtgat gactactggg acaccaatga 2460 tgccaatgtggtttgcaggc agctgggctg tggctgggcc acgtcagccc caggaaatgc 2520 ccggtttggccagggttcag gacccattgt cctggatgat gtgcgctgct caggacatga 2580 gtcctatctgtggagctgcc cccacaatgg ctggctctcc cacaactgtg gccatcatga 2640 agacgctggtgtcatctgct cagcttccca gtcccagccg acacccagcc cagacacttg 2700 gccaacctctcgtgcatcaa cagcaggatc tgaatccact ttggccctga gactggtgaa 2760 tggaggtgacaggtgtcgag gccgagtgga ggtcctatac caaggctcct ggggcaccgt 2820 gtgtgatgactactgggaca ccaatgatgc caacgtggtc tgcaggcagc tgggctgtgg 2880 ctgggccatgtcagccccag gaaatgccca gtttggccag ggctcaggac ccattgtcct 2940 ggatgatgtgcgctgctcag gacacgagtc ttacctgtgg agctgccccc acaatggctg 3000 gctctcccacaactgtggcc atcatgaaga tgctggtgtc atctgctcag ctgctcagtc 3060 ccagtcaacgcccaggccag atacttggct gaccaccaac ttaccggcat tgacagtagg 3120 atctgaatccagtttggctc tgaggctggt gaatggaggt gacaggtgtc gaggccgagt 3180 ggaggtcctgtatcgaggct cctggggaac cgtgtgtgat gacagctggg acaccaatga 3240 tgccaatgtggtctgcaggc agctgggctg tggctgggcc atgtcggccc caggaaatgc 3300 ccggtttggccagggctcag gacccattgt cctggatgat gtgcgctgct cagggaatga 3360 gtcctacctgtggagctgcc cccacaaagg ctggctcacc cacaactgtg gccatcacga 3420 agacgctggtgtcatctgct cagccaccca aataaattct actacgacag attggtggca 3480 tccaacaactacaaccactg caagaccctc ttcaaattgt ggtggcttct tattctatgc 3540 cagtgggacattctccagcc catcctaccc tgcatactac cccaacaatg ctaagtgtgt 3600 ttgggaaatagaagtgaatt ctggttatcg cataaacctg ggcttcagta atctgaaatt 3660 ggaggcacaccataactgca gttttgatta tgttgaaatc tttgatggat cattgaatag 3720 cagtctcctgctggggaaaa tctgtaatga taccaggcaa atatttacat cttcttacaa 3780 ccgaatgaccattcactttc gaagtgacat cagtttccaa aacactggct ttttggcttg 3840 gtataactccttcccaagcg atgccacctt gaggttggtc aatttaaatt catcctatgg 3900 tctatgtgccgggcgtgtag aaatttacca tggtggcacc tgggggacag tttgtgatga 3960 ctcctggaccattcaggaag ctgaggtggt ctgcagacag ctagggtgtg gacgtgcagt 4020 ttcagcccttggaaatgcat attttggctc tggctctggc cccatcaccc tggacgatgt 4080 agagtgctcagggacggaat ccactctctg gcagtgccgg aaccgaggct ggttctccca 4140 caactgtaatcatcgtgaag atgctggtgt catctgctca ggaaaccatc tatcgacacc 4200 tgctccttttctcaacatca cccgtccaaa cacagattat tcctgcggag gcttcctatc 4260 ccaaccatcaggggactttt ccagcccatt ctatcccggg aactatccaa acaatgccaa 4320 gtgtgtgtgggacattgagg tgcaaaacaa ctaccgtgtg actgtgatct tcagagatgt 4380 ccagcttgaaggtggctgca actatgatta tattgaagtt ttcgatggcc cctaccgcag 4440 ttcccctctcattgctcgag tttgtgatgg ggccagaggc tccttcactt cttcctccaa 4500 cttcatgtccattcgcttca tcagtgacca cagcatcaca aggagagggt tccgggctga 4560 gtactactccagtccctcca atgacagcac caacctgctc tgtctgccaa atcacatgca 4620 agccagtgtgagcaggagct atctccaatc cttgggcttt tctgccagtg accttgtcat 4680 ttccacctggaatggatact acgagtgtcg gccccagata acgccgaacc tggtgatatt 4740 cacaattccctactcaggct gcggcacctt caagcaggca gacaatgaca ccatcgacta 4800 ttccaacttcctcacagcag ctgtctcagg tggcatcatc aagaggagga cagacctccg 4860 tattcacgtcagctgcagaa tgcttcagaa cacctgggtc gacaccatgt acattgctaa 4920 tgacaccatccacgttgcta ataacaccat ccaggtcgag gaagtccagt atggcaattt 4980 tgacgtgaacatttcctttt atacttcctc atctttcttg tatcctgtga ccagccgccc 5040 ttactacgtggacctgaacc aggacttgta cgttcaggct gaaatcctcc attctgatgc 5100 tgtactgaccttgtttgtgg acacctgcgt ggcatcacca tactccaatg acttcacgtc 5160 tttgacttatgatctaatcc ggagtggatg cgtgagggat gacacctacg gaccctactc 5220 ctcgccgtctcttcgcattg cccgcttccg gttcagggcc ttccacttcc tgaaccgctt 5280 cccctccgtgtacctgcgtt gtaaaatggt ggtgtgcaga gcgtatgacc cctcttcccg 5340 ctgctaccgaggctgtgtgt tgaggtcgaa gagggatgtg ggctcctacc aggaaaaggt 5400 ggacgtcgtcctgggtccca tccagctgca gaccccccca cgccgagaag aggagcctcg 5460 gtaggtggtcgctctcagac cccactgtcc accggggcgc agacccctga ctcggggact 5520 tgggatgttcctcttggtgt catattccaa ctcagattga gccctacatt gtgctgcacc 5580 tggtcatacggagttgaatc agacctggtt cccgcctccc ccaaggctca tggtccttgg 5640 aggacccgttgcagggcgag gtcaagagag ttctgacctg gatggcccat agacctgacg 5700 tcccagaatccatgcttctc atctgcaaaa tgaaaatgtc aatacttact tcttagcact 5760 gttgagagggttacttacat aaaggaattt tggtgaaact gc 5802 <210> SEQ ID NO 5 <211> LENGTH:7379 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE: 5agtattctta ccatcatctt tccctgctgt gctcccggca gacaattcta atctgtcatg 60acactctgat gatcccagac ccagctgcat tatcattctc agtccaacac tccaggaacc 120aagggatcac aatccccttc taagaggaat ccagcatgtg cctggtcttg ggcattccct 180ggtaggtgag taaccctgtt ctctcgtcac ccagtgctta tcagttgctg atctggcagt 240aggaggatga aacacagtga gcctattctg tgttcctatt ctactcaagg ggtgaagagg 300cacctggaaa caacaggaag agttgtagga ttaaaaagga catccaagat tgaatgtaac 360tttcatctgg atgaagccaa aggcagactt ccagccctaa attctgactg gtggctgaca 420caggacatgg gttcatggta cccttctaga atgcagcata gactactgat gaacagtgca 480tggcaaagaa gccaagtgtc atttcatggc ctcagcctct cagctgagaa gcagggcaca 540gctcacccag gctaggaaaa cagaggcaag tcctggaaag ctgtctgctt ttaaccaaga 600gttactggcc atcaagtgtc ttggttaaaa aataagtgtc aggcaacctt cttggtagat 660agagtgtgtt gggggcgatt atcagagtct ggtaatgact tctgagggtc ccaaagagtg 720aagtgatatt tacatagcaa atccaaggag ggggattgtg tgcaatatag gtggaggtgg 780gggcaggttt tgtgggtttg ccaagctcca agggtcatac aatgtgcatg tcaaggacaa 840gaaatcaaag ccatgtgaaa tggttggagg tggttcagtt tgaggtcatg tgtttctcag 900ctcctgttgt ggaattagtg tgagacccag aagactgtgg ccaaagctat tatggaccca 960tggtctctgt ggactcatcc ctcatgcctt ctgctctctg atcacatcca cactcatgtc 1020atcctcgttc ttccaaggtg aggttactag cactgcacag gggctgatga gagcatgtcc 1080tgccaggaaa aaccatccca aagagatgct ttcccccttg gcactgtgtc ctgtatttgc 1140tcagcagccc acatcctgtt ctgccccaaa ccttggggca gacttcccac aggtgaattt 1200gaactcccca agattaaaat caagcctgta ttcaggaaac acttgggagt cctcgaggtt 1260caccgagagg gaagttggaa atttttcact tatgtcagtg cgtttgcagt tgggcaacag 1320ccagattgtt catatggcaa tcaatcaaac acacctaagt tttttccaca tattagccat 1380cgactgttag caaaagccct cacttccttt atattgattt atagcagcag cagaaatata 1440ccaccctaga ggacacacct ccttttagct aggtacctat aaatgtccag gattttctat 1500tcaattgaga agaacccagc aaaatgggga tctccacagt catccttgaa atgtgtcttt 1560tatggggaca agttctatct acaggtatta cgtttaatta ttatattcat taatttctct 1620cctgcagacc caatcatggc aaattatatc tactactttc cattacaagg gaagttttat 1680atcaaagagt gggtagcact ttgctgataa ttgtaattgt ttgcaggtat tcaggaggaa 1740tggctctttt ttgttttatt tctggctgag aaatataaat ggttgtagtt agaaaaagcc 1800agtcattaag tcaatgtttt cagtaagtca ttcaactaaa ggaatgattg atttgtctta 1860gaaaaatccc tgaagtttag gaaaggtgga tgtgtattat taagaggccc ttaaactttg 1920cagcaattgg ttaaacacac agtttgtgtg ctatgaaaac ggacagaaag gattcccact 1980gcaaatgccc tttatgtggc ttctttctac aggtgtgtct ggcttgatgg ctaatatttg 2040ccgagcaaaa tcaggtcaag taattgagcg cagacaagat cattaagatt ccaagtttgt 2100cttggaattc caagtttgtc tgtcatgcac agctttaaac aaacacttga agcccagtca 2160ctcaagcata gctgtatgtt cttagagagt cagatgataa acgtgagaga gccgtcggta 2220gcgcactctg attgctgcat ctcaatggca ttttgcagag atactagagg aacaagtgat 2280tctcagtttg cctattctgt ctctctcttc ctctctctct gcctctctct ctctctctct 2340ctctctatct ttctctctta tctattgtgt agttattatc atcttttctc tcccctctct 2400ctccctctgt ttctgtctgt ctgtgtttct ctctctctct gtatctttct ctttttccca 2460tcttttgggc agatatcacc ttttcttcct cctcctccct ctgtttctgt ctctgccttt 2520ctctccctgc ccccctcact gtatcttcct gtctttctca tctatcaggc agttattacc 2580tttcctccct ccctcctccc ccttctctgt ttctctctcc atctctcttt ctctttattg 2640ggcagctatt atcacctttc tctctgtctc tgtctctgtc tctctttctc ttcaactatt 2700gggcaactat tatcacctct cctctctctc tctatctgtt tctcttcatc tgtcaggcag 2760ctattatcac cttccctccc cctctctttt tctctctcac tctttctcat catctattgg 2820gcagctctta tcacttttcc tccctatttc tctctctctc tctccctttg tttctatctt 2880ctttctacct tccttccatc cctttttctt tctctccctc tctttattca tttctttctt 2940ccttcttctc ttttatcttt cctactgcct tttttttctt ttatgtcacc ttttgctaga 3000tttatgaatt tcaggataca gggtaaaaat cacctaattt tcaggtaact tccggaactc 3060tcactctccc cctaggctca gtgggggaag atttgaagat taaggttcat ctggttggtt 3120gctttcatga aagcagcacc tcccaaccca gccctcacac ccgggtggta gggagcaggc 3180ccaccccctg tgatgagcgt gtggagggcc tgggggccac taggcccagg acctcagggg 3240agtggagact gggcatcctc atcctgcctc catcagaagc atctgaaact gggaggctgc 3300gtcctcagcc ccagctcttg tcagtaccga gttcaccctc cagattgtct ctgaaccatg 3360acatggaatt cacatcagcc actgtagaca gggagtgaat tgccttgtct ttatctacaa 3420agaaacaaca ggcagcagtg ctcttggatt gaggacattt gtagtttgcc catgatgttt 3480tgtgcatgca tatggacaga catgcacata tgtgcatgca tgcctgtgtt tgccattcag 3540aggtgggaat tcatgctctc tgaagtggac ccgtattctc ttatttaaat cttctaacat 3600tcctgaagtt aggaacaatt atttccacat ttcagatggg gaaactgagg ctcagaaagg 3660ttattggctt gtccaaagac agcactggtg agtggctggg ttagggcttg aatctggatc 3720aaattcacta gcattcagat gacagctctg gcccactggc ccttgctgct ccttgcaggg 3780aactgaggtg atgaactgaa ctgtggcatc taactcagtg cttggagcct gaccacagag 3840ctttgtgctg gaagtaccga ggtggcaggc acctgtcagc tctggtcttc atgcaaactc 3900ttgagaaaaa ctcagtatgc ccaggtttgt gctgggcagg aaaggctgtg gtacccactg 3960ctagccccag caatgcccct cctctgccac ttgcctgctg tggatcctct gtgaccctca 4020gtttactcat ttataaatgg aggttatgtt ccaacccatg caatatctgg cacatagaca 4080gagcctcaga accatttagt gttactactc tagacatttt cctcatgttt tatccaaaag 4140cagcttccta aaagtaatgt gagctcttgg attggatcct gcaacagaaa atgaaaaact 4200ggtgaaatcc agataaagcc tggagtaaac ttagtaggaa ggtaccagtg tttgttagca 4260tgagaatcac ttgaactcag gaggcagagg ttgccgtgag ccgagattgt gccactgcac 4320tccagcctgg gtgacagagt gagactctgt ctcaaaaaaa aaaaaaaaaa ttaataaatc 4380attttccaga agtgattctt ctcccttcag gcaatttacc accattccca caatggcagc 4440tggagtaacc tacagctatg tggttgattc ttggaagact acagattggt ctcagtatgt 4500gcagaagggt ctattcaaaa tgtgtggaca cagcagaacc aggaacaact tcaatgtggt 4560gttccatgct gtggatgagc cttgtcaagg ctctggctgg atgagttcga ctgccatggg 4620attaggcagg atacctggga cctggcagtg ggaattgcat ggtgtcaggt agactgtgtt 4680taaatggccg agttttgaat ggaaggctct cttaggcaca tctatcagct cgttcttgag 4740tgtgggagca gggatggcac gtcagaaaag aggtggggat gttctggtac agagttccct 4800agtttgctat ctctgttgaa agaatgttgt ggtttctatt ccgagtttct tcttcatttt 4860aagggatgca tagccacatg gtttcagtgg cccccttcct aagccatcaa tatgaagcag 4920ggcagctggg ggagcccatc gtggagctca tattcaggct gttgaggcag gtgaagatgt 4980tctctgacat atggcaagtc ctgtcactgg cctgttggtt ccattagaga aattcaaatc 5040tctgaactgt gactgtcact gctctcagga cccacattta caaagaatct gaagagccgg 5100gcgtggtggc acatgcctgt agttccagct actctagggc tggaggcagg aggcttgctt 5160gaacccagga atttgaatct agcctgggca atagagcaag actctatctc taaaagtaaa 5220ataataatct gataattttg tcaaatgcct taatcctcct tttaccagga agtaaaaaga 5280aaaggaataa tgaaagtatg ctggaattgt taataagaat ttaaacatag cagacctttt 5340tatatcacat acattttggt atataaacat cataaaagac aaaagaatac catcacaggt 5400attttttttt ttttagcaaa ataagatggt tgaagttctt gttgcaaaat atcatgtgat 5460gaaatcccta tcgaagtgtg taagagtacc gtattttatt tttgtcctta gaattgtatc 5520attgaccctg gattcttgaa tttgagaaat tcatctagga tatcaccatc tgaagactca 5580tagtctgaga tttctgttgt acaatcaatt ctaccattat tagtatctgg agtgctatat 5640cttgtctcta tattcctctt ctggttcatc taattattgc aaaaacatct tctcttgtca 5700gttttcttct ctttgccatc acaagtagaa aatgaaaaaa tttgaattct taactgcatt 5760caatgaaagc taaaaacaga ctatgaagaa agtgtctcca gtcttaaaaa aaaatcttct 5820tgaaagataa tacaatactt tgggcatgga agaattatga cttatttcac tagttcatct 5880tccttctagg caacttcacc attctaccat tttcttacta tttaataatt gatgaataat 5940gatgcaatac tttcttggat gatgaaatag tgaaatgctt caagacatag gaaaaataaa 6000atcagaagcc aataatgaat cttggattta taaaaggatc taatggatcc atatggtgat 6060tacaagatag gatgagtttt atcctttttt ttaaatgaat aaatactctc tctgatcttt 6120gaaagacctc taaaatatat aaaagttgtg aaatatcaac actcacgagt atagttagaa 6180ctgctcaaaa agaaactcaa aagctacagt tgagtccgat ggaccttgtc tggcctcact 6240gaatataaag atccagggat ctctagattt ccatttgctt caagatggaa taaaatattt 6300tcaggttatg agtcagaagg aacagaatat ctgacattaa catattttct tctttagggg 6360tcatctgagt ggctgttgca gctatactca aatttcagac tggacaacca gcttaagctg 6420tcttctcttg tccagccctt ctttccaagc atagattaca tcctgtcacc ataagctgta 6480gtgttagggg cctagtaaag agacatatgc ttcattacat ctaaaatgat tgagctcctc 6540atatccaatc cacttgcttt aatccgctat tgcagaattc atttagcaag aacgtcgggg 6600acacacaaac ccaagattga gccacagcgc cctctggtgt gattgtacgg tgaagcgaaa 6660gccaatttct gtgacttgta ggaaatcatt tctaaacagt gtttctaaga cgaatttgtg 6720ttctttccag gtgggtggat cccaaggact acagactacg gtaagacctt ttcttcactc 6780ctcttccctg gtggggttgg ccagttctcc tctgctgctg ttggctagtt gaggctgagc 6840acagctgagg tcacagagca aacgcctgcc ttgtcgaacg caggaatgcc ggggggacag 6900gagacgtggg tgccaagacc tggggcatgt ctcaagtgcc cactcggcca atcccagctg 6960tcattctcct tcctcttgct ctctgactct cagtcattta tcagatgagg ttagtttcag 7020tttggtgtga ggagagatag ttgaaaataa aggttagtac cttttctttt ttttcttttt 7080cttttttctt ttttttttga gacggagtct tgctcaccct gtcaccagac tggagtgcag 7140tggtgcaatc tcagctcact gcaacctccg cctcctgggt tcaagcaatt ctcctgtctc 7200agcctccaga gtagctggga ctacaggtgc gcgccaccac gcccagctaa tttttgtagt 7260tttagtagag atggggtttc accatgttgg ccaggatggt cttgatctct tgacctcgtg 7320atccacccac ctcggcctcc caaagtgctg gggttacagg catgagccac tgcgcccgg 7379<210> SEQ ID NO 6 <211> LENGTH: 29598 <212> TYPE: DNA <213> ORGANISM:Homo sapiens <400> SEQUENCE: 6 gtacacgtgt atgtgctctg cattttacttgctttgctgt aagtgatggc tgaatgacgt 60 ttggagggta agtagtattg ccccttttcatagacaatga aggtcaagcg gttatcttcc 120 tgtccttctg aagttggatg tggtggaggtaggcttcagt ctcagcccct cagagcctgc 180 tgatgcaatc acttcagcag catcacgacctggcctggga taccaaatat acatcttcct 240 aagtggcagt ttctcccttt ttaaaatttgaggagggtgg gagaactctt gggacttaag 300 acataaatgt atatcaacat cagattgaggagggaaccca ggcattctat ttactggaaa 360 ttaagtgaca aataaaagat acttaacatgctcaatggaa aagagaactt cccctggacc 420 taacccagca agtcccagtg ctgatttcctttgttcacat agtgccagga tgtgtgcaga 480 caccaagagg tttttttaat tcacaaagaaacctacaagg acactgtccc atggcgtgat 540 ccccaaagag gagtttctgg ttaaactgtctacttcaaga gcaactctgt catttggagt 600 gtgggctgga ctgagcccat gccaccatgcctggggtgtg cccttggtaa tccaaccacc 660 aagtgggact gggctcccca agggggcatcgtcctccatg cagccacttt gtgagtggtt 720 tagttttgca ttctggaaag gttggttttctttcgaaacc accttttttc tggttgaacc 780 accttctcag gtatatttca gtgatggtggatatttgtca tttgagggtg tgtttgagcc 840 atagaaaccg ccagatgtct tttgacattcaatcttgtga ctagcatggg gttgtgaatg 900 gactgggtga ctttttgaat agaggctgtggcagcagagg agatgggggt agggtaataa 960 gagtaaagga tgctcatgtg gcatcctagcccagtctggg gccagtacaa tgacaaagcg 1020 attggcacat ggttggcttt tagcaatggatggtgccgtt aggacctgtg cttccagccc 1080 ttgcttcaga gctgagcaag ccctggaccaaccctcccca agcgagggct acgatcaatg 1140 agctcttcct ttctccaccc tgcaggttctctgattccct cagagtcaac cctggagtca 1200 actgtagcag aaggtaacgt ctactatgggggatccctgt agactcatta cccccctgca 1260 cccctaggtt aatctctgat tcagatgaggtgcagagggc atagaaagta gggtgcttag 1320 ctcccacgag gggcccttcc acaaaaggcctcaggtctga acaggtatat cttgcatcga 1380 tcatgtctga gactgaggag gaatcaacttgaagacgcgt ctccaaggag ttctcagtgg 1440 agccttttat tctgtctcta gagattctgttatctttgct tgttgctcac tcctgtgttc 1500 ctcacccagc tgtgctcatc cgtggccagcctagggttct ggatctctgg ctacagggcc 1560 ttgagggtca ggtgcctacc tgctaacgtagccaaattgc taggacagca tccttgccct 1620 tgccctttct ttaagcctat attatgccacccttgtttct tcttaacaga gagaaatcac 1680 aatccttcag ctcatgggca tcagagctcatgtacttccc ccttgggtat ctccagtgag 1740 aaatctggga gacatagtca atacatcctgggattctggc agcctgggct ttgggaaggg 1800 aagtcacttc ccatttccca tgggaaatcttggccctagg agaagctcaa ggacaacatt 1860 ctcaccaagg cctctgcgct gcccagggttggcatgcagt tgggaatgct gatggtacat 1920 gcatcgggcc ctcctgttcc tcaggtcgtcttctttcttc tcccttctcc ctctggccca 1980 tggggtgagg tctgacttaa cctcttcctctttcctatga tgaaggacac agaagacact 2040 tgaagtgagg gtgagactgg ctttattctgacttagccat gtcccttcgc aagattccca 2100 cattttctta tttgcagcag ctataagaggagaatctgtt ccttcctctt gagtggtttc 2160 ccctgaggtc cctgttacat gttaaggaccacaccttggt gggacaagcc ctttggtata 2220 actggtccag ccagggatgg gagtgagggggcagaggtat ttggctgatc tgcctgtcac 2280 acaggactgc agataggact tacctggagttgctcttatc aggaactcta gtgtcagctg 2340 ggagtcacat ttcttctaga tctggagacctcacgtagca gcccagtgga gagctcagac 2400 agaagctgag tgctgtggct gcagtgggttaagggtaact ctcagatcac ttcctctcca 2460 agccccagca ctcagtcagc tcctgtaggtgccctggaca aattccaggg ctctggagca 2520 attcaaaaac ggagattcca agccagtatcttacttaaag gggaatatta gaagcatttc 2580 tgctaatgtg aaaaacaagg caagtatgccctccatctcc actgctgttc aatgttgtac 2640 tggaggtagt agccaatgca atgagagaagagaaatcaat tagaggccta agcatgggaa 2700 aagttatttt tgcatccctc ttctggagttctgtataggt tacatgtagg cacatcggaa 2760 tcagagtgag tatgttggta cagaaatatttcctccccaa gcagcccttt agaatcaaag 2820 aactcaatgc tagacaggtt tcttgactttcccaaattta cacagcaaga caatatccag 2880 atcaggagtg atggctcctc agcagatcctagtttacttt cagcccatga gtgtcttcag 2940 aggagaccta actttatatt ttctggttttttttgggggg gtgtggtggg gtttgttttt 3000 catcttctac aattggcaaa agcagagactaccactacaa atactgagtc tactgttgtg 3060 acaggtaatg agtaactttg aatccctttctgtaggtcat gttgccaact atatccatgg 3120 gctttactgt tactcaggaa aaattttagggaatgggatg ggagggaatg ttgtgagtac 3180 acagtgacct tctggatccc agaggtcagctagagtgaag cttccttcat tgcccatgtt 3240 cctggaggta gggagaaatc agtcagaatatggtgtctcc aagagcctgt gtgctttgga 3300 agcagagacc agtgggatca gtctccagtccagagtgaca gcccagctcc cccatctcca 3360 cagctctgtg ctgaccctaa caatcctggccctgaggaag gctataaggc caggaatatc 3420 acgtgacaaa tgtgctccaa accaaccttagagctgcaga tacacatcag agctcctccc 3480 gggacatctt gatgttatcg tgctgctcttcagtgtgggg tgttgtgtgt cccctgtctg 3540 agggaatcag gcagagccca tggtctgcttagagaagggt catgtgtatc tctaggtccc 3600 ctccaggatg cagatcagga ggagccttttattctgctcc agctgaagct ctaaggcttg 3660 ggtttgggcc aagcagtcac tgtcctcttccccatgaaga actctaacct taaggcctgt 3720 taaagcccag cccaattaga gattctctcaaagatatctg cctatgggga agaccctgaa 3780 tgccctgcag gccctgagac cttgtgcctcagtaggaatg tgcaagagaa attctgtgcc 3840 ttcctctagg atctgattct ggtttggccctgaggctggt gaatggagat ggcaggtgtc 3900 agggccgagt ggagatccta taccgaggctcctggggcac cgtgtgtgat gacagctggg 3960 acaccaatga tgccaacgtg gtctgtaggcagctgggttg tggctgggcc atgtcagctc 4020 caggaaatgc ctggtttggc cagggctcaggacccattgc cctggatgat gtgcgctgct 4080 caggacacga atcctacctg tggagctgcccccacaatgg ctggctctcc cataactgtg 4140 gccatggtga agatgctggt gttatctgctcaggtaggca tccagatctc tggagggttg 4200 ggtgtggtgg ctcatgcctt taatccccacactttgggag gatgaggtag gcagattgct 4260 tgagctcagg cgttcaagac cagctctaggcaagatggca aaccccatct ctattaaaaa 4320 aagaaaatca cttgggccca ttctggggacagactgtatt cagagaatat agtaacaggt 4380 ttctcactcc agggcccccg cccaagtctttcctggttat ctggtggctc tggagtttag 4440 ttggggcagt tggcctgtgg gtacaatgccacggtcagca caaatcccca agctgcgagc 4500 agtgccgcaa cattggtttg gaggtgactgaggcaccagt gttcagacac agggtccagc 4560 atgctgacat cagaaatgat gagctttttattctgctcca ggaacatccg cataactcat 4620 acccccattt tccccgaggc tccttctcagggacagcacg ttttggggat ctggttggtg 4680 aagccttccc tccccttgaa cactgtattaccttgagtgt tgtcagccgc tgacccagag 4740 ggaaggatgc aattgtaaat agttcacttatgattgctgt gaagagaggc agggaagtgg 4800 ggtaagggtg ggaggatggc agtgagtcgcaaatggtggg ctcacgagtg agctcagcat 4860 agggagcagg gggacctcct agagtatcaccaggaatcca cgtcaaacct cagactcatc 4920 gcagctcaag cgtggagagt tagggtcttcatctactcat tgcttagggt ggctgtttgc 4980 tgctccctgg gtgttgatac cgaggttgttgtggccggtc ccaggcaccg aagtgacctt 5040 catatccctg gagagtgagc cacaggcacagagaaggcaa tgccaggggc tgtggggtcc 5100 ctgagggacc gagggcttca cggtgggcactggcagggcc cacttggtgg gcgtgtgatg 5160 ggcatcagct cagggtgtag ataccccaagtcacttcagc cttaactcta cttggagtca 5220 ctgagtgttt ggtgtctaat gttgctatttttttctcaca gctgcccagc ctcagtcaac 5280 actcaggcca ggtgagtccc cagaatccttcctcgggata ccccttctct ttctgctcag 5340 ttaccccttc cctactccac agagccctcctgcttctctg cagatactct ggggcatatt 5400 atttcacccc caactctgta actgagaccctagcatgggg cttcttaacc acacatggga 5460 tttagcttct gccttctctt cagtccatctcagctttcat cacacagttc catgctgtcc 5520 caatgaacaa ctcttagaag ttcagaaagaagcctgctgt ttaatgagct ttggcctctt 5580 tatattcagg gctgacacaa cctttctgggaattgagggt gagactctct aatgttctgt 5640 tgaaggcaag gtcagtacag gcttgatacccccatctctc actacttgaa aaacccccag 5700 attctgcagg gccacgtctg cattcagaagaggcagaggc catgctgagg ggagagagag 5760 gctaagaaat gtttctggtg ccttcacttaccaggaaacc tgatttcccc cagggcggac 5820 ccctagtatc ccgaacattt tagctgcaagtgtcaagtct tggcagtggt gtcagatgag 5880 ccagtcagtc cacgcgtcag tggatggtgggggatggggg tggtgaaggt ttcctaactg 5940 cgaataggtc atccctctct cagagagaggtggaagggcc tgcatggtgt cctttgtccc 6000 tgaatgagtt ccctgggcag gagacctgggcagacacatg gggagcaagt ggccagacct 6060 tcgagtggaa ttgttttcac agtgcttgcctggtccagag aaccgcttgt tttttacctt 6120 tttcccttca agtccaattg tatcctttctctttgttgct gtttacagaa agttggcctg 6180 tcaggatatc accacctgta cccacagaaggtaaagaatc ctctcaacac tccctggggc 6240 tcactttcta cctctggata cactttggatttcatagttc acttatgatt gccataaaga 6300 gaggtgggga agtgggctaa gcgtgggagggtggcagcag gtgataaaca gttggctcaa 6360 gagtcagctc ggcactggga acaagagcaggacctcccag aagatcatta agaatcatta 6420 ggctcatgat aggatgaggc tcaaggtgggccccttgctt tttcatgttt ctgtgggttg 6480 ggtagggagg aagctggagt ctctgaaaacccagaattag atgtgatatt ggagggtgga 6540 gggtgctggt gacctgtctc ctgtgggatcctgttccaag tggtcagaaa agatccttat 6600 ctatgggctc agaacaagcc ctgggggtctccctaatcct atggggacct catccctgcc 6660 atctctggta ctctgccagt cagatcccagataggaccat gctcctgaat aagggagggg 6720 tctgggcctg ccatctggag ctgagcagctccatcctctg tgtacccaac tggggagtgg 6780 ggcatccatt cccatcacat ccactggggtcacaggtgct tccccaaaag ttgagcatcc 6840 atagacctgg gcagagtagg ttatcagtgctactttcacg gtgatgaagc ctagtctgtg 6900 gtcatatgca aaggtgactg cctgcctaggtgacttagtt cattaggaag taccctgagt 6960 gtggaactta ccttagattc ttgacctcatgatagggatg gatgaagggt tcttgtgttc 7020 ccctgtagga tctgaatcca gtttggccctgaggctggtg aatggaggcg acaggtgtcg 7080 aggccgagtg gaggtcctat accgaggctcctggggcacc gtgtgtgatg actactggga 7140 caccaatgat gccaatgtgg tctgcaggcagctgggctgt ggctgggcca tgtcagcccc 7200 aggaaatgcc cagtttggcc agggctcaggacccattgtc ctggatgatg tgcgctgctc 7260 aggacacgag tcctacctgt ggagctgcccccacaatggc tggctcaccc acaactgtgg 7320 ccatagtgaa gacgctggtg tcatctgctcaggtgggcct tcaagaactt gggctcactc 7380 tcttggggtg gagtttgctc caaaagaaactcctaattac attctgatct cctcactcaa 7440 agcttctatg ttttctatgt ttctgaagacttgtcagctc tctgctaaga atccatatgt 7500 actcactgcc tagtgttcct gtggtcacttaggacagggg atcaaactaa aacaacccag 7560 agtttttccc cttcctgagg caaggcaaggaagaggcaga agagaaaagt gccggctccc 7620 cagggctcca tttctcccct gctgagtagcacggtgtgag ggtataatgg atgcagcaca 7680 gacagcaagg caggggaggg atcccctcactgcgaggaac tctgaactaa agatgcttgg 7740 ctaaaagtgg gttctcagct gagacccagtgaggaggtct ggaaatagag gctcaagggt 7800 taggagtgca aatgggtgtc tgtttgtatcaggcctgggt tgcgtggggt tggagttctt 7860 gacctcagct cttctcagaa cgctgctgagcattgcctgt gttctaggtc tggtgagggg 7920 agggcagtcc ccatgaggcc agccagacatggccttgtca ttgcctgtga ttggggcttg 7980 aagatcgcac aagggatttt ggctggagtggcttcctcag ccttgctgac tcaggaacac 8040 ctaagatgtg caagggagtg ggttggtttaggtcaaccgg gttaccctgg gcagacacaa 8100 tttgatcacc tcagagctgg caatagtggacaggatctgc ctcgacccct tacacggtgc 8160 atctctgtgg ggatgtgcat ggcaatgtccctccctgtgt gataggaact aggatggact 8220 gagtgtcaga ctcgctcatt tctttccctcctcgttccag ttttgccgac ttctgtgtaa 8280 tgttcctgat ctgaccttct cttctctttctcacagctcc ccagtcccgg ccgacaccca 8340 gcccaggtag gtccccagtg tccttcctcaaaatgtccct tctctttctg cccaatcacc 8400 ccttccacac tccacagagc tctcctgtttctctgtgtgg atactgtggg gcatattatt 8460 tccaccccca acaccggctg tgtaactgagatcccagcac agcgcttttt aaacacacac 8520 aggattgagg aggcctctgt cttcttttcaacccctctca gctttcatga aacagtttca 8580 tactgtccca gtggacaacc cttacaggttcaggaagtgg ccccatgttt aatgagcttt 8640 ggtcctttta tattccggac tcacatatagtttctgaaaa ttgagggtgt caccctctga 8700 cccgttcaag gcatcgtcag ggcaggctcgatacccccat ccatcactgc tggaaacatt 8760 ccgagattat gattccgaga tttctatccagaagaggcag agtttgtgct cgggcaggga 8820 gagggataat aaaggtttgt gatgtctctgcttaaccaga aacctgattc ctgattgtcc 8880 cctgggcagc ccctggttcc cctaacattttacctggcag tgtccgagct tcagcaatgg 8940 cgtctgatgt cctagtcagt ccatgcatcagcagatgtgg gatggcatgg tgggggcatc 9000 ctctaacaga tagaaagata ccccaggattacagaaatgg agggctcagt ctggtctcca 9060 gcaggacctt tgtccctgga tgagttcacagcacaggaga cctgggaaga cacatgggaa 9120 acaaatggca ggaacaagaa gtggaattgttgtcacgttg attcctcctc ccagagatcc 9180 ttttgttctg tgccttttcc cttcaagtctaattctgtct tttccttttg ttgcaattta 9240 cagatacttg gccgacctca catgcatcaacagcaggtaa ataaccctct cacccctccc 9300 taggactcac tatctctgga catattttgtgtttgaaact gataggatga ggctcaatgt 9360 gggcttctct gttttcatgt ccctgtgggttgcgtgggag gaaggtggaa tctctgagga 9420 gccagtcctg ggtctgatgt ttgaggacggagggtgttgg tgacctgtct cccatggaat 9480 cctgttccaa gtggtcagga aagatcctcatccaggtgct caggacgagc actggagggc 9540 tccttaatgc tgctgggacc tcattcctggccctcaggcc atgggatcca gacctctgaa 9600 gagcgggtga aagtgccggt ccctgcacctgtgtggccaa ggccttgcca tcactggcaa 9660 tttgccagaa ggcagagagg cccatgcaggtgccaataag ctcctgaata tggagggggt 9720 ctaggcctgt catttgtagc tgtgtagctccatcctgtgt tcacccagag tggggagtgg 9780 ggtgtccatt cctgtcctct cctctggggtcatacatgct tacccatagc ttgagctttt 9840 atagacttga gtagaatagg gcatcactttttccactatg accaagctta acctctgggt 9900 gcagccatct gccattgtga ctgcgtgccctggtgacttt ggcatttgta ttcaaacttg 9960 actacttttc ccattgccct gagtgttgtccatgcctttt ccttcacctc agaatggaga 10020 tggatgaagg attcttgtgt tcccctgtaggacctgaatc cagtttggcc ctgaggctgg 10080 tgaatggagg tgacaggtgt cagggccgagtggaggtcct ataccgaggc tcctggggca 10140 ccgtgtgtga tgatagctgg gacaccagtgacgccaatgt ggtctgccgg cagctgggct 10200 gtggctgggc cacgtcagcc ccaggaaatgcccggtttgg ccagggttca ggacccattg 10260 tcctggatga cgtgcgctgc tcaggctatgagtcctacct gtggagctgc ccccacaatg 10320 gctggctctc ccataactgt cagcacagtgaagacgctgg tgtcatctgc tcaggtgggc 10380 ctccaagacc ttgggctccc tctcttggggtagattttgc tcaggaagcg aggtctcatt 10440 atgttctgat ctcctcactc agagctttttcagcctttcc tatatatctg atatctcctt 10500 agctctctcc taggaaactg catgagtcttcattgccagg ttttgaggag gtcaggtagg 10560 acaacgggcc aaagtgaaat aagggtcacgcctttgttca cctaccgagg cagcgcaagc 10620 agagggagaa gaggaaagtg ccaggtctttgccttttagt gtggctggaa aggaatagct 10680 ggggctggtt tgttcatgag gaaagaggctgatttgggtc ttggctttgc aggctgcata 10740 ggaccatggt gcaggcgtct gctcagcttctgatgagggc ctcgggctgc ttgtactcct 10800 agcagaaagg gatggggagg tggcctgggcagaggtcaca aggtgaggga ggaaggaaga 10860 gagagcaaga gggagggctc agactcttcaaccaccagct cttgctagga actaagagaa 10920 gaactcaccc ctgaccaggg agggcactaagttattcatg cagtgttggt ctccatgacc 10980 cagacctggt gcatcaggcc tcacctctaaacttggggat tcagttgcaa tataacactt 11040 ggatgtgaca agcctctaaa gtatagcaccctggctctcc agggttccat ctttccccta 11100 ctgaaagatt ttgcaaaggg ttacatggatgaagcacata tagaggatgg gggagggact 11160 gtctccctgg gaggagccca gaaccacaggctcctgctag gaagcgcggt cttctgctga 11220 ggcccaataa ggtgatgtct taatagagacacaaggctag gagtgcggat gtgtgtctgt 11280 ccctctctgg cctgagattt gggggctgtgagtccttgac cacaactccc tccagagcac 11340 tgcagtgtct tgcctgtgca ccggtctggtgtggagtgtg cagtccccat gaggtctgct 11400 aggcaaagca ttgttatgaa cgcctgtgggctggactgga acatcagagg caggactttg 11460 gctggagtgg cctcctcaca tttgctaactcagggactgc taagacatgc aagggagagg 11520 gtaggttttg tgtcaacctg attactatgggcagacacaa ggttaatcac cttggagttg 11580 gcaatagtgg acaggatctg cccagacaccctccaaggag catctctgtg gggacatgca 11640 tggcaatgcc ctccctctgt gatggggacctagggtggac tgaaggcatg atctgtttag 11700 ttccttccac ctttgttccg attttgccagcttctgtata gtgcatctga tctgacctcc 11760 tctttctcac agctgcccac tcctggtcgacgcccagtcc aggtgagtcc ccagtgtcct 11820 tccttgggat gtcccttctc tttctgtataattatccctt tctgcactcc acagagccct 11880 cgttcttctc tgagtgaata ctacatggcatacaattttc ccctgctctg taactgagac 11940 cctggaatgg cgcttctgaa ccagacatagggttcaagag gcttctgtct tctgttccat 12000 ttatctcagc tttcatgaag cagtttcatactgtcccagt ggccaaccct tagaggttta 12060 ggaagtggcc tcatatttaa atagctttgacccttttcta ttcagagctg atatgacctt 12120 cctgagaatt gagagtgatt gccaaagtctcctcggaagc caatgtcagc taaagcctta 12180 aacatggctg ccgccatggg caagcaatgtcagtgcaggc ctgacacctc ccttcctcac 12240 tccttccaac acccagattc tgcagcgctacatgtgcatc cagaagaggc ataggccatg 12300 ctcgggcagg gagagggata ataaatatttctggtgcctc cacttactgg gaaacttgat 12360 acccctttgg tcagctcctt ggtttccctaacgttttagc tcgagctagt agagtgtcag 12420 caatggtgtt agatgtaccc gtcagtgcatgtgtcagtgc atggaacagg ctaacccttt 12480 gtgactgaga agaggacatc ccacacttcagaggcaggag ggatcgaact ggtctccagc 12540 aaggcttatg tcccttgctg agcttgctgagctgcagact tgggcagaca catggggagc 12600 aaagtggcag gaatcagaag tggggtagttttcatgatgc tcgccttctc cggagacttt 12660 tccttttgga gattttcacc atcaactttaattctagcct ttgtctctgt tgcaattaca 12720 gacacgttgc cgaccatcac cttacctgcatcgacagtag gtaaataatc ctctcgcccc 12780 tccctagggc tcactctcta cctctggacaaatgtttttt tctgaaatga taggatgagg 12840 gtcaaggtgg gcccctctgt ttttcatgtccctgtgggtt gcatgggagg aaggtagagt 12900 ctctggggac ccagctgtgg gtctgatgttggaggctgga gggtgctggt gacttttctc 12960 ccgtggaatc ctgttccaag tggtcaggaaacatcctcat ccaggtgcca aggaaaagcc 13020 ctggaagctt ccctaatcct actaagacctcattcctgtc cctcagccca tgggctgcag 13080 aggtgtgaag agtcagtgaa agtgagtgtccccacacctg tctggccaag gccttgtcat 13140 acctgtgaaa ttttcagaag ccagacaggaccataggatt gccaccaagc tcctgagatg 13200 gggagagtct ggcctgccta ctgtagctgtgtagctccat cctgtgtgtg cccaggttag 13260 ggaatggggt ttccgttcct gttaactccagtagggtcac aggtgcttcc ccaaacttga 13320 gccttcataa acccaggcag aactgcttctttgactttga tgaagctgaa tctctggttt 13380 tattcatatt caaaggtgac tgcctgcccaggtgacttta gccattagga cgtgccttga 13440 gtgtggaaca ttccttagat tcttgacctcatgataggga tggatgaagg gttcttgttt 13500 tcccctgtag gatctgaatc cagtttggccctgaggctgg tgaatggagg tgacaggtgt 13560 cagggccgag tggaggtcct ataccgaggctcctggggca ccgtgtgtga tgacagctgg 13620 gacaccaatg atgccaatgt ggtctgcaggcagctgggct gtggctgggc catgttggcc 13680 ccaggaaatg cccggtttgg tcagggctcaggacccattg tcctggatga cgtgcgctgc 13740 tcagggaatg agtcctactt gtggagctgcccccacaatg gctggctctc ccataactgt 13800 ggccatagtg aagacgctgg tgtcatctgctcaggtgggc ctccaagact tttggtttcc 13860 tctcttgggg tagattttgc tcaggaaggttttattatgt tctaatctcc tcacttagag 13920 ctttttcaac ttttcctata tttctgatacctccttagct ctctcctagg aaaccgcatg 13980 agtcttcacc acattgccag gttttgaggaggtcagagag gacaatgggc caaagtgaaa 14040 taagggtcac acctttgttc ccctactgaggcagcgcaag cagagggaga agacgaaagc 14100 gccgggtctt tgccttttag tgtggctggaaaggaatagc tggggccagg ttgttcatga 14160 agatagaggt tgatttgggt cttgggtctttgcaggctgc ataggagcat ggtgcaggca 14220 tctgctcggc ttctgctgag gacctcaggctgcttgtact cctggcagag gggatgggga 14280 gctggcctgg gcagaggtca catggcgagggatgaagcaa gatggcagaa gaagatgggg 14340 aggtggcctg gacagaggtc acatggtgagggaggaagca agaaagagca agagggaggg 14400 cccagacagt tttcaaccac cagctctttctaggaactaa gagaagaact tacccctgac 14460 cagggaggac actaagttat tcatgaagagttggccttca tgacccagac atggcacatc 14520 aagcctcacc tctatacttg gggatccaatcccaacatga gtcttagatg ggacaaacat 14580 ccaaactata gcatgctgcc tctccagggttccacctttc ccctactgaa aggtttaggt 14640 gagggtgagg tggatgcagc acatataggcattgagggag ggacggtctg actgggagga 14700 ttccagaacc aagggctcat gctgggaagggagggttttc tgctgaggac taataaggag 14760 gcatcagacc ggaaacacaa ggctgggagtggagattcgt gactgtccat atctgacctg 14820 ggttttgggg gtgtgagtgc ttgattgcaattccctccag agcactgcag tgtcttgcct 14880 gtgcaccggt caggtgtggg gcaggcagtgcccatgaggc ttactgagca aagccttgtt 14940 atgaatgcct gtgggctggg ctagaagatcacaggctgga tatttttttt ttgcaggagt 15000 ggcctcttca tacttgctga ctcagggactgctaagatgt gcaagggagt gggttggttt 15060 tgtgtcaacc tgattactat gggcagacacaaagtccttc aaacaccccc agatgcagca 15120 gggccccatc tacatgcgga aaggcagaggccgtgctcag gcaaggagag agatattaga 15180 tatttctggt acctccactt gccaggagactttatactcc tttgggcagc tccctgatcc 15240 ttctaacatt ttagctgtaa caatcagaggctcagcaatg gtgtcagatg tgtccattag 15300 tccatgtgtc agtggatggg gcaggcaaaccctttgtagc tgagaagagg atatcccaca 15360 cttcagaggt aggagggatt ggactggtctccagcgaggc ctatgtccct tcctgagctt 15420 actgggctga agagttgggc agacacatggggagcaagtg gcaaaaacca gaaatccagt 15480 agttttcatg atgcttgccc tatctggagacttttccttt tggagctttt caccctcaag 15540 tttaattcta gcctttgtct ttgttgcaattaaagacacg ttgccgacca ccacattacc 15600 tgcatcaaca gtaggtacag aatcttctcacccccactag ggctcactct ctacttctgg 15660 acaaatgttt ttttctgaaa atgagaggatgagggtcagg gtgggtccct gtctttttca 15720 tatccctgtg cattgagtgg gaggaagttggagtctctgg ggagccagtc ctgcttctgg 15780 tgttggaggg tagagggggc tggtgacctgtctcccttgg gatcctcttc caagtatcag 15840 gaaataataa agaaaaaaaa aaaagatcctcatccaggtg ctgaggacaa gccctggagg 15900 gctccctact cctattcgac ctcgttcctggccctccagc catgcactgc agacctgcaa 15960 gggtgggtga cagtttctgt ccctgcagctgtctggccaa agccttgcca tccttggcaa 16020 tttgccagaa gccagggagg accatgggggtgccacctaa ctcttgaaca tggggacagc 16080 atggtcctgc cctctggagc tgtggagctccatcctgtgt gtgcccagag tagggagtcg 16140 gttgtctatt cctgtcacct ccactggggtcacaggtgct tccccaaaac ttgagccttc 16200 ataaacccaa ggagaatagt gtatcacctctccttctact gtgatgaagc tgaacctctg 16260 gttgcagtca tctttaatcg tgactgcctgcccaggtgac tttggccatt aggaagtgcc 16320 ctgagtgtgg aatgtgcctt agatccttgacctgctgata gggattgatg aagggttctt 16380 gtgttctcct ataggacctg aatccagtttggccctgagg ctggtgaatg gaggtgacag 16440 gtgtcagggc cgagtggagg tcctataccgaggctcttgg ggcaccgtgt gtgatgacag 16500 ctgggacacc aatgatgcca atgtggtctgcaggcagctg ggctgtggct gggccacgtc 16560 agccccagga aatgcccggt ttggtcagggctcaggaccc attgtcctgg atgatgtgcg 16620 ctgctcagga catgagtcct acctgtggagctgccccaac aatggctggc tctcccacaa 16680 ctgtggccat catgaagatg ctggtgtcatctgctcaggt gggcctccag caattttggt 16740 ttcctctctt ggggtagatt ttgcccaggaagagaggtct tatgttctaa tctcctcact 16800 cagagctttt tcaacctttc ctatgtttctgatatctcct tagctctctt ctaggaaact 16860 gcatgagtct tcaccacagt gccaggttttgaggaggtca gagaggacaa tgggccaaag 16920 tgaaataagg gtcatgcctt tgttcccctaccaaggcagc gcaagcagag ggagaagagg 16980 aaagggctgg gtctttgcat tttagtgtggctggaaagga atggctgggg tcaggttatt 17040 catgaagaaa gaggcagatt tgggtcttggctttgcaggc tgcataggag cgtggtatct 17100 gcttggcttc tgctgacagc ctcaggctgcttgtgctcct ggcagaagga gatggggagg 17160 tggcctgagc agaggtcacg tggcaagggaggaagcaaga gagggcaaga aggaaggccc 17220 aggctctttt caaccaccag ttcttgctagaaactaagag aagaactcac ccctgatcag 17280 ggagggcact aagttgttca tgaatggttggcttccatga cccagacatg gcacatcagg 17340 cctcacctct atacttgggg atccaatcccaacatgagtc ttgtatggga caaacatcca 17400 atctatagca cactggctct ccagggttccatctttcccc cactgaaagg tttaggtgag 17460 ggtgaggtgg atggagcaca tataggtgttgggggacgga cgatctcacc gggaggagtc 17520 cagaaccaaa ggcttatgct gggaagggagggtcttccgc tgaggcccag taaggaggca 17580 tcagactgga aacacaaggc tgggagtgcagatctgtgtc tgtccaagtc tggcctgggt 17640 tttgggggtg tgagtgcttg actgcaattccctccagagc actgcagcat cttgcctgta 17700 caccagtcag gtgtagggcg ggcagtgcccattagggctg ctgagcaaag ccttgttatg 17760 aatgcctgtg ggctgggcta gaagatcacaggctggattt ttgctggagt ggcctcttca 17820 tacttgctga ctcagggact gctaagacgtgtaagggaga gggttggttt tgtgtcaacc 17880 tgattactgt gggtagacac aaacttaatcactttggagc tggcagtagt ggacaagatc 17940 tgcccagatg cctttcaagg agcatctttgtggggacgtg catggcaatg cccctccctc 18000 tgtgatgggg acatagggtg gactgaaggcgctaccagtt tagttccttg tacctttgtt 18060 ctggttttgc cagcttctgt atagtgcatctgatctgacc tcctctttct cacagctgcc 18120 cagtcccggt cgacgcccag gccaggtgagtccccagtgt ccttccttgg gatgtccctt 18180 ttctttctgc acaattatcc tttttcccattccacagagc cctccttctt acctgtgtgg 18240 atactgtggg tcatactatt ttccctgctctgtaactgag accctagcat ggagcttctt 18300 aaccagacat ggttaagaag gtatgatctttctaagaatt gagagtgatt gccaaagtct 18360 cctgggaagg caatttcagc taaagccttaaacatgcctg tccatgggca agaatgtcag 18420 tgcaggcctg atacctccat tcctcactccttcagacacc cccagatgcg gcagggcccc 18480 atctacctcc agacaggcag aggctgtgctcaggcaggga gagcgatatt agatatttcc 18540 gttgcctcca cttgccagga gactttatactcccttaggc agctccctga tccttctaac 18600 attttagttt caagcgtgag aggctcagcattggtgtcag atgtgcccat cagtccatgt 18660 gtcagtggat ggggcaggta aaccctttgtagctgagaag agggtattcc acacttcaga 18720 ggcaggaggg atcggactgg tctccagtgaggactatgtc cctggctgtg cttcctgagc 18780 tacagacttg ggcagacaca tggggagcaagtggcaggaa ctagaaatgg aagaatattc 18840 atgatgcttg ccttgtccag agacctttccttttggagct tttctccctc aactttaatt 18900 ctagcctttg tctttgttgc aatttacagacacgttgtcg accatcacgt tacctccatc 18960 gacagtaggt aaataatcct ctcacccctccctagggctc actctctacc tctggacaaa 19020 tgttttctct gaaaatgata ggatgagggtcaaggtgggc ccctgtcttt ttcacatccc 19080 tgtgcgctga gtgggaggaa gttgagtctctggggaacca gtcccgggtc gggtgttaga 19140 gggtggaggg tgttggtgac ctatctcctgttggaccgtg ttccaagtat cagtaaagat 19200 cctcattcag gtgctggaca aaccctggagagctccctac tcctgggacc tcattcctgg 19260 ccttctggcc atgcattgca gacctgcaagggagggtgaa aatttctgtc cctgcagttg 19320 tctggccaat gtgttgccat ccctggcaatttgccagaag ccagagagga ccacgtgggt 19380 gccaccaaac tcttcgacat ggggatagcataggcctgcc ctctggagca gtggagctcc 19440 atcctgtgtg tgctcagagt agggagtggggtgtccattc ctgtcacctc cactggggtc 19500 acaggcgctt tcccaaaatc tgagcctccataaacccagg cagaataggg tatcacctct 19560 ccttccagta tgatgaagct gaacctctggttgcagtcgt attcaatcgt gactgcttgt 19620 ccaggcgacc ttggccatta ggaagtaccctgagtgtgga acgtgcctta gatccttacc 19680 tcatggtagg gatggataaa gggttcttgtgttcccctgt aggatctgaa tccagtttga 19740 ccctgaggct ggtgaatgga agtgacaggtgtcagggccg agtagaggtc ctataccgag 19800 gctcctgggg caccgtgtgt gatgacagctgggataccaa tgatgccaat gtggtctgca 19860 ggcagctggg ctgtggctgg gccacgtcggccccaggaaa tgcccggttt ggccagggct 19920 caggacccat tgttctggat gatgtgcgctgctcaggaca cgagtcctac ctgtggagct 19980 gcccccacaa tggctggctc tcccacaactgtggccatca tgaagatgct ggtgtcatct 20040 gctcaggtgg gcctccaaga ccttgggctccctctcctag actggagttt gctcaggaag 20100 aaaatcctaa ttacattctg atctcctcactcaaagattc ttctatgttt cctatattta 20160 tgtagtcttg ttagctctct gctaaggatctgtatgaatt ttactacagg gcttggtgtt 20220 cctgtggtca cttaggacag gccccaaactgaaacaacaa cccagacttt atccccttcc 20280 tgaggcagtg caagaaagag gccgaagagaaaactgctgg ctccccaggg ttccatttct 20340 cctcagctga gtagcactgg gtgagggtatcatggacata ggacagacag caaggtaggg 20400 gaggaatcct ctcactgaga ggaactctgagctaaagatg cttgtctgaa agtgagttct 20460 cagctgagac ccagtgagga ggtctggaaatagaggctca agggttagga gtgcaaatgg 20520 gtgtctggtt ctatcaggcc tgggttgtgtgaggttggag tccttgacct caggtcctct 20580 cagaacgctg cagagcactg ccttgccctgggtctggtgt ggggagggca gcccccatga 20640 gacaggccag gcatggcctt gttattgcctgtggtcgggg cttgaagatc acacaaggga 20700 ttttggctgg agtggcttcc tcagccttgctgactcagga acacctaaga tgtgcaaggg 20760 agtgggttgg tttaggtcaa ccgggttaccctgggcagac acaatttgat cacctcagag 20820 ctggcaatag tggaaggatc tgcctcgaccccttacacgg tgcatctctg tggggatgtg 20880 catggcaatg tccctccctg tgtgataggaactaggatgg actgagtgtc agactcgctc 20940 atttctttcc ctcctcgttc cagttttgccgacttctgtg taatgttcct gatctgacct 21000 tctcttctct ttctcacagt ttcccagtcccggccgacac ccagtccagg taggtcccca 21060 gtgtccttcc tcaaaatgtc ccttctctttctgcccaatc accccttcca cactccacag 21120 agctctcctg tttctctgtg tggatactgtggggcatatt atttccaccc ccaacaccgg 21180 ctgtgtaact gagaccccag cacagcgctttttaaacaca cacaggattg aggaggcctc 21240 tgtcttcttt tcaacccctc tcagctttcatgaaacagtt tcatactgtc ccagtggaca 21300 acccttacag gttcaggaag tggccccatgtttaatgagc tttggtcctt ttatattccg 21360 gactcacata tagtttctga aaattgagggtgtcaccctc tgacccgttc aaggcatcgt 21420 cagggcaggc tcgatacccc catccatcactgctggaaac attccgagat tatgattccg 21480 agatttctat ccagaagagg cagagtttgtgctcgggcag ggagagggat aataaaggtt 21540 tgtgatgtct ctgcttaacc agaaacctgattcctgattg tcccctgggc agcccctggt 21600 tcccctaaca ttttacctgg cagtgtccgagcctcagcaa tggcgtctga tgtcctagtc 21660 agtccatgca tcagcagatg tgggatggcatggtgggggc atcctctaac agatagaaag 21720 ataccccagg attagagaaa tggagggctcagtctggtct ccagcaggac ctttgtccct 21780 ggatgagttc acagcacagg agacctgggaagacacatgg gaaacaaatg gcaggaacaa 21840 gaagtggaat tgttgtcacg ttgattcctcctcccagaga tccttttgtt ctgtgccttt 21900 tcccttcaag tctaattctg tcttttccttttgttgcaat ttacagatac ttggccgacc 21960 tcacatgcat caacagcagg taaataaccctctcacccct ccctaggact cactatctct 22020 ggacatattt tgtgtttgaa actgataggatgaggctcaa tgtgggcttc tctgttttca 22080 tgtccctgtg ggttgcgtgg gaggaaggtggaatctctga ggagccagtc ctgggtctga 22140 tgtttgagga cggagggtgt tggtgacctgtctcccatgg aatcctgttc caagtggtca 22200 ggaaagatcc tcatccaggt gctcaggacgagcactggag ggctccttaa tgctgctggg 22260 acctcattcc tggccctcag gccatgggatccagacctct gaagagcggg tgaaagtgcc 22320 ggtccctgca cctgtgtggc caaggccttgccatcactgg caatttgcca gaaggcagag 22380 aggcccatgc aggtgccaat aagctcctgaatatggaggg ggtctaggcc tgtcatttgt 22440 agctgtgtag ctccatcctg tgttcacccagagtggggag tggggtgtcc attcctgtcc 22500 tctcctctgg ggtcatacat gcttacccatagcttgagct tttatagact tgagtagaat 22560 agggcatcac tttttccact atgaccaagcttaacctctg ggtgcagcca tctgccattg 22620 tgactgcgtg ccctggtgac ttacgtgccctggtgacttt ggcatttgta ttcaaacttg 22680 actacttttc ccattgccct gagtgttgtccatgcctttt ccttcacctc agaatggaga 22740 tggatgaagg attcttgtgt tcccctgtaggatctgaatc cagtttggcc ctgaggctgg 22800 tgaatggagg tgacaggtgt cagggccgagtggaggtcct ataccgaggc tcctggggca 22860 ccgtgtgtga tgatagctgg gacaccagtgacgccaatgt ggtctgccgg cagctgggct 22920 gtggctgggc cacgtcagcc ccaggaaatgcccggtttgg ccagggttca ggacccattg 22980 tcctggatga cgtgcgctgc tcaggctatgagtcctacct gtggagctgc ccccacaatg 23040 gctggctctc ccataactgt cagcacagtgaagacgctgg tgtcatctgc tcaggtgggc 23100 ctccaagacc ttgggctccc tctcttggggtagattttgc tcaggaagcg aggtctcatt 23160 atgttctgat ctcctcactc agagctttttcagcctttcc tatatatctg atatctcctt 23220 agctctctcc taggaaactg catgagtcttcattgccagg ttttgaggag gtcaggtagg 23280 acaacgggcc aaagtgaaat aagggtcacgcctttgttca cctaccgagg cagcgcaagc 23340 agagggagaa gaggaaagtg ccaggtctttgccttttagt gtggctggaa aggaatagct 23400 ggggctggtt tgttcatgag gaaagaggctgatttgggtc ttggctttgc aggctgcata 23460 ggaccatggt gcaggcatct gctcagcttctgatgagggc ctcgggctgc ttgtactcct 23520 agcagaaagg gatggggagg tggcctgggcagaggtcaca aggtgaggga ggaaggaaga 23580 gagagcaaga gggagggctc agactcttcaaccaccagct cttgctagga actaagagaa 23640 gaactcaccc ctgaccaggg agggcactaagttattcatg cagtgttggt ctccatgacc 23700 cagacctggt gcatcaggcc tcacctctaaacttggggat tcagttgcaa tataacactt 23760 ggatgtgaca agcctctaaa gtatagcaccctggctctcc agggttccat ctttccccta 23820 ctgaaagatt ttgcaaaggg ttacatggatgaagcacata tagaggatgg gggagggact 23880 gtctccctgg gaggagccca gaaccacaggctcctgctag gaagcgcggt cttctgctga 23940 ggcccaataa ggtgatgtct taatagagacacaaggctag gagtgcggat gtgtgtctgt 24000 ccctctctgg cctgagattt gggggctgtgagtccttgac cacaactccc tccagagcac 24060 tgcagtgtct tgcctgtgca ccggtctggtgtggagtgtg cagtccccat gaggtctgct 24120 aggcaaagca ttgttatgaa cgcctgtgggctggactgga acatcagagg caggactttg 24180 gctggagtgg cctcctcaca tttgctaactcagggactgc taagacatgc aagggagagg 24240 gtaggttttg tgtcaacctg attactatgggcagacacaa ggttaatcac cttggagttg 24300 gcaatagtgg acaggatctg cccagacaccctccaaggag catctctgtg gggacatgca 24360 tggcaatgcc ctccctctgt gatggggacctagggtggac tgaaggcatg atctgtttag 24420 ttccttccac ctttgttccg attttgccagcttctgtata gtgcatctga tctgacctcc 24480 tctttctcac agctgcccac tcctggtcgacgcccagtcc aggtgagtcc ccagtgtcct 24540 tccttgggat gtcccttctc tttctgtataattatccctt tctgcactcc acagagccct 24600 cgttcttctc tgagtgaata ctacatggcatacaattttc ccctgctctg taactgagac 24660 cctggaatgg cgcttctgaa ccagacatagggttcaagag gcttctgtct tctgttccat 24720 ttatctcagc tttcatgaag cagtttcatactgtcccaat ggccaaccct tagaggttta 24780 ggaagtgacc tcatatttaa ttagctttggcacttttcta ttcagagctg atatgacctt 24840 cctgagaatt gagagtgatt gccaaagtctcctgggtagc caatgtcagc taaagcctta 24900 aacatggctg ccgccacagg caagcaatgtcagtgcaggc ctgacacctc ccttcctcac 24960 tccttccaac accccagatt ctgcagggctacatgtgcat ccagaagagg cataggccat 25020 gctcgggcag ggagagggat aataaatatttctggtgcct ccacttactg ggaaacttga 25080 tacccctttg gtcagctcct tggtttccctaacattttag ctcgagctag tagagtgtca 25140 gcaatggtgt tagatgtacc cgtcagtgcatgtgtcagtg catggaacag gctaaccctt 25200 tgtgactgag aagaggacat cccacacttcagaggcagga gggatcgaac tggtctccag 25260 caaggcctat gacccttgct gagcttgctgagctgcagac ttgggcagac acatggggag 25320 caagtggcag gaaccagaag tggggtagttttcatgatgt ttgccttctc cggagacctt 25380 tccttttgga gattttcacc atcaactttaattctagcct ttgtctctgt tgcaattaca 25440 gacacattgc cgaccatcac cttgcctgcatcgacagtag gtaaatattc ctctcgcccc 25500 tccctagggc tcactctcta cctctggacaaatgtttttt ctgaaaatga taggatgagg 25560 gtcaaggtgg gcccctctct ttttcatgtccctgtgggtt gcatgggagg aaggtagcgt 25620 ctctggggac ccagctctgg gtctgatgttggaggctgga gggtgctggt gacttgtctc 25680 ccgtggaatc ctgttccaag tggtcaggaaacatcctcat ccaggtgctg aggaaaagcc 25740 ctggagggtt ccctaatcct actaagacctcattcctgtc cctcagccca tgggctgcag 25800 aggtgtgaag agtcggtgga agtgactgtccccacacctg tctggccaag gccttgtcat 25860 acctgtgaaa ttttcagaag tcagacaagaccataggatt gccaccaagc tcctgagatg 25920 gggagagtct ggcctgccta ctgtagctgtgtagctctgt cctgtgtgta cccaggttag 25980 ggaatggggt ttccattcct gttaacttcagtagggtcac agatgcttcc ccaaaacttg 26040 agccttcata aacccaggca gaatagggtgtcactgcttc tttgactttg atgaagctga 26100 atctctgatt ttattcatat tcaaaggtgactgcctgccc aggtgacttt agccattagg 26160 acatgccttg agtgtggaac attccttagattcctgacct catgataggg atggatgaag 26220 gattcttgtg ttcccctgta ggatctgaatccagtttggc cctgaggctg gtgaatggag 26280 gtgacaggtg tcagggccga gtggaggtcctataccaagg ctcctggggc accgtgtgcg 26340 atgacagctg ggacaccaat gatgccaatgtcgtctgcag gcaactgggc tgtggctggg 26400 ccatgtcagc cccaggaaat gcccggtttggtcagggctc aggacccatt gtcctggatg 26460 atgtgcgctg ctcaggacac gagtcttacctgtggagctg cccccacaat ggctggctct 26520 cccacaactg tggccatagt gaagacgctggtgtcatctg ctcaggtggg ccttcaagaa 26580 cttgggatca ctctcttggg gtggagtttgctccagaaga aactcctaat tacattctga 26640 tctcctcact caaagcttct tctatgttttctatatttct gaagacttgt tagctctctg 26700 ctaagaatcc ctatgtactc actgcctagtgttcctgtgg tcacttagga caggggacca 26760 aactcaaaca acccagagtt tttccccttcctgagggaag gcaaggaaga ggcagaagag 26820 aaaagtgctg gctccccagg gctccatttctcccctgctg agtagcacgg tgtgagggta 26880 taatggatgc aggacagaca gcaaggcggggtagggatcc tctcactgtg aggaactctg 26940 aactaaagat gcttgtctga aagtgggttctcagctgaga cccagtgagg aggtctggaa 27000 atagaggctc aagggttagg agtgcaaatgggtgtctgat tctatcacgc ctgggttgtg 27060 tgaggttgga gtccttgacc tcaggtcctctcagatcact gctgagcatt gcctgtgccc 27120 caggtctggt gtggggaggg cagcccccatgaggccggcc aggcatggcc ttgtcattgc 27180 ctgtgatcag ggcttgagga cggcacaagggattttggct ggagtggctt cctcagcctt 27240 gctgactcaa gaatgcctaa gacgtgcaagggagagggtt ggtttaggcc aaccgggtta 27300 ccctgggcag acacaagttg atcacctcagagctggcaat agtggacagg atctgcctcg 27360 accccttaca tggtgcatct ctgtggggatgtgcatggca atgcccctcc ctgtgtgata 27420 ggaactagga tggactgagt gtcagactcgcccatttctt tccctcctcg ttccactttg 27480 ccgacttctg tgtaatgttc ctgatctgaccttctcttct ctttctcaca gcttcccagt 27540 cccggccaac acctagtcca ggtgggtccccagtgtcctt cctcaaaatg tcccttctct 27600 ttctgcccaa tcaccccttc cacactccacagagctctcc tgtttctctg tgtggatact 27660 gtggggcata ttatttctac ccccaacaccagttgtgtaa ctgagacccc agcacagcgc 27720 tttttaaaca cacacaggat tgaggaggcctctgtcttct tttcaacccc tctcagcttt 27780 catgaaacag tttcatactg tcccagtggacaacccttac aggttcagga agtggcccca 27840 tgtttaatga gctttggtcc ttttatattccggactcaca tatagtttct gaaaattgtg 27900 agtgtcaccc tctgacctgt tcaaggcatcatcagggcag gctcgatacc cccatccttc 27960 actgctggaa acattccgag attatcatgggccacatttg tatccagaaa aggcagagtt 28020 tgtgcttggg cagggagagg gataataaaggtttgtgatg tcactgctta accagaaacc 28080 tgattcctga ttgtcccctg ggcagcccctggttccccta acattttatc tgccagtgtc 28140 cgagcctcag caatggcgtc tgatgtcctagtcagtccat gcatcagcag atgtgggatg 28200 gcatggtggg ggcatcctct aagagatagaaagatacccc aggattagag aaatggaggg 28260 ctcagtctgg tctccagcag gacctttgtccgtggatgag ttcacagcag aggagacctg 28320 ggaagacaca tgggaagcaa gtggcaggaacaggaagtgg aattgttgcc aggtggattc 28380 cccctcccag agaacctttt gttctgcaccttttcccttc aagtctaatt ctgtcttttc 28440 ctttgttgca atttacagac acttggccaacctcacatgc atcaacagca ggtaaataat 28500 cctctcaccc ctccctaggg ctcactgtctctggacatat tttgtgtttg aaactgatag 28560 gatgaggctc aaggtgggcc cctcttttttcactcccctg tgggttgcgt gggaggaagg 28620 tggaatctct gaggagccag tgctgggtctgatgtttgag gatggagggt gctggtgact 28680 gtctcccatg gaatcctgtt ccaagtggtcaggaaagatc ctcatccagg tgctcaggat 28740 gagcactgga gggctcctta atcctactgggacctcgttc ctggccctca ggccatggga 28800 tccagatctc tgaagagcag gtgaaagtgccagtctctgc acttgtgtgg ccaaggtctt 28860 gccatcactg gcaaattgcc agaaggcagagaggaccatg caggtgccaa tgagctcctg 28920 aattcggagg gggtctgggc ttgtcatttgtagctgtgta tctccatcct ttgtgtaccc 28980 agagtgggga atggggtgtc cattcctgtcccctcctctg gggtcataca tgcttaccca 29040 tagcttgagc ttttatagac ttgagtagaatagggcatca ctttttccac tatgacaaag 29100 cttaacctct gggtgcagct atcttccatcatgactgcat gccctggtga cttctgcatt 29160 cgtattgaaa cttgactact ttgcccactgccctgattgt tgtccatgcc ttatccttga 29220 cctcatattt gagatggatg aagcgttcttgtgttcccct gtaggatctg aatccagttt 29280 ggccctgagg ctggtgaatg gaggtgacaggtgtcagggc cgagtggagg tcctataccg 29340 aggctcctgg ggcaccgtgt gtgatgactactgggacacc aatgatgcca atgtggtttg 29400 caggcagctg ggctgtggct gggccacgtcagccccagga aatgcccggt ttggccaggg 29460 ttcaggaccc attgtcctgg atgatgtgcgctgctcagga catgagtcct atctgtggag 29520 ttgcccccac gatggctggc tctcccacaactgtggccat catgaagacg ctggtgtcat 29580 ctgctcagnn nnnnnnnn 29598 <210>SEQ ID NO 7 <211> LENGTH: 28720 <212> TYPE: DNA <213> ORGANISM: Homosapiens gatctgcctc aaccccttac acggtgcatc tctgtgggga tgtgcatggcaatgtccctc 60 cctgtgtgat aggaactagg atggactgag tgtcagactc gcccatttctttccctcctc 120 attccagttt tgtcgacttc tgtgtaacat tcctgatctg accttctcttctctttctca 180 cagcttccca gtcccagccg acacccagcc caggtaagtt cccagtgtccttcctcaaaa 240 tgtcccttct ctttctgccc aatcacccct tccccactcc acagagctctcctgtttctc 300 tgtgtggata ctgtggggca tattatttct accgccacca ccggctgtatttcacatggg 360 tccttttcta ttttccctaa gtgtcagccg gtctgagaaa taaagggaaggcatacaaaa 420 gagcaaaatt ttaaagctgg gtgttggggg gagacatcac atgtcagcaggttccgtgat 480 ccctcctgag tagcaaaacc agcaagtttt tattggtgat tttcaaaaggggagggagtg 540 cacaaatagg gtgtgggtca cagagatcac atccttcaca aggtaataaaatatcacaag 600 gtaaatggag gcagggcaag atcacaggac tggggtgaaa ttaaaattgctaatgaagtt 660 tcgggcacgc attgtcattg aaaacatttt atcaggagac agggtttgagagcagacaac 720 tggtctgacc aaaatttatt aggaggcaat ttcctcatcc taataagcctggaagcgcta 780 cgggggaccg gggcttattt catcccttat ctgtaagcgt aaaagacagacgttcccaaa 840 gcggccattt cagaggcctc cccttaggaa cacattctct ttctcagggatgttccttgc 900 tgagaaaagg aattcagcga tatttctcct atttgctttt gaaggaagagaaatgtggct 960 ctgttctgcc tggcccacag gcagccagcc tttaaggtta tctcccttgttccctgaaca 1020 acgctgttat cctgttcttt tttcacagtg cccagatttc atattgtttaaacaatttct 1080 gcagttaacg caatcatcac agggtcctga ggtgacattc atcctcagtttatgaagaag 1140 atgggattaa gagattaaag taaagacagg cataggaaat cacaagagtattgattgggg 1200 aagtgataag tgtccatgaa atcttcacaa tttatgttca gagattgcagtaaagacagg 1260 cgtaagaaat tataaaaata ttaatttggg gaactaataa atgtccatgaaatcttcaaa 1320 tttatgttct tgtgccatgg cctcagccgg tccctctgtt tggggtccctgacttcccgc 1380 aacacagcac agtgctttga aaacacacat aggattcagg aggcctctgtcttcttttca 1440 acccctctca gctttcatga aacagtttca tactgtccca gtggacagcccttacaggtt 1500 caggaagtgg ccccatgttt aatgagtttt ggtcctttta tattcaggactcacatatag 1560 tttcgaaaat tgagggtgtc accctctgac ctgttcaagg cattgtcagggcaggctcga 1620 tacccccatc catcactgct ggaaaaattc tgagattatg atggaccacatttgtatcca 1680 gaagaggcag ggtttgtgct tgggcaggga aagggataat aaaggtttgtagtgtctctg 1740 cttagccaga aacctgattc ctgattgtcc cctgggcagc ccctggttcccctaacattt 1800 tatctgccag tgtctgagcc tcagcaatgg catctgatgt cctagtcagtccatgcatca 1860 gcagatgtgg gattgcatgg tggggggcat cctctaacag atagaaagataccccaggat 1920 tagagaaatg gagggctcag tctggtctcc agcaggacct ttgttcatggatgagttcac 1980 agcagaggag acctgggaag acacatggga agcaagtggc aggaacaggaagtggaattg 2040 ttgccaggtt gattccccct cccagagaac cttttgttct gtgccttttcccttcaagtc 2100 taattctgtc ttttttcttt gttgctattt acagacactt ggccaacctctcgtgcatca 2160 acagcaggta aacaatcctc tcacccctcc ctagggctca ctatctctggacatattttg 2220 tgtttgaaac tgataggatg aggctcaagg tgggcccctc tcttttcatgtccctgtggg 2280 ttgggtggga ggaaggtgga gtttctaggg agtcagccct gggtttgatgtttgaggatg 2340 gagggtgctg gtgactgtct ctcatgggac cctgttccaa gtgttcaggaacgatcctca 2400 tccaggtgct caggacgagc actggaaggc tccctaatcc tgctgggacctctttcctgg 2460 ccctctgacc acgcactgca gacctgcaag ggtgggtgaa aatttctgtccctgcagctg 2520 tctggccaag tccttgccat ccctggaaat ttgccagaaa ccagagaggaccatgtggat 2580 gccaccaaac tcttaaacat ggggccagca tgggcctgct ctctggagctgtggagctcc 2640 atcctgtgtg tgcccagagt agggagtggg gcattcattc ctgtcacttccagtggggtc 2700 acaggtgctt ccccaaaatc tgagcctcca taaacccagg cagcatagtgtatcacctct 2760 cctttcccta tgataaagct gaacctccgg tagcagttgt atgcaattgtgactgcttgc 2820 ccaggtgact ctggccatta ggaagtaccc tgagtgtgga acttgccttagattgttgac 2880 ctcctggtgg ggatggatga agggttcttg tgttcccctg taggatctgaatccactttg 2940 gccctgagac tggtgaatgg aggtgacagg tgtcgaggcc gagtggaggtcctataccaa 3000 ggctcctggg gcaccgtgtg tgatgactac tgggacacca atgatgccaacgtggtctgc 3060 aggcagctgg gctgtggctg ggccatgtca gccccaggaa atgcccagtttggccagggc 3120 tcaggaccca ttgtcctgga tgatgtgcgc tgctcaggac acgagtcttacctgtggagc 3180 tgcccccaca atggctggct ctcccacaac tgtggccatc atgaagatgctggtgtcatc 3240 tgctcaggtg ggctttcaag accttgggct ccctctctta agttgaagtttgctcaggaa 3300 gaaaatccta attacattct gatctcctca ctcaaagctt tttctatgttttctatattt 3360 ctgaagtctt gttagctctc tgctaagaat ctttatgaat tttgctacagtacctggtgc 3420 agctgtggcc acttaggcca gggctccgaa ctgaaacaac aacccagactttatccccat 3480 cctgaggcag tgcaaggaag aggcagaaga gaaaagtgct ggctccccacggctccattt 3540 cttccctgct gagtagcact ggttgagggt atcgtggaca cagcacagatagcaggggca 3600 gggagggatc ctctcactac aaggaactgt gaactaaaga tgcttgtctggaagtgggtt 3660 ctcagctgag acccagtgag gaggtctgga aatagaggct caagggttaggagtgcaaat 3720 gcatgtctgt ttgtgtcagg cctgcttgga gtccttgacc tcaggtcctctaagaatgct 3780 gcagagcact gcctgtgccc caggtctggt gtggggaggg cagcccccatgagtctggcc 3840 aggcatggcc ttgttattgc ctgtggtcgg ggctgtaaga tcacacaaggcatttgggct 3900 ggagtggcct cctcagcctt gctgactcag gaactgccaa aacatccaagggagagtgtt 3960 ggttttgggt caacctggtc accctgggca gacacaaagt tactcacctcggagctgaca 4020 atagtggcca ggatctgcct gcacccctta tatggtgcat ctctgtgggaatttacatgg 4080 caatgcccct ccctctgtga tagggactag gatggactga gtgtcaggcttgcccagttc 4140 cttctatctt tgttccagtt ttgccatttt ctgtatagtg catctgatctgaccttctct 4200 tctctttctc acagctgctc agtcccagtc aacgcccagg ccaggtgagtccccagcatc 4260 cttcatcggg atgtcccttc tctttctgcc cagttacctc ttccccactccacagagctc 4320 tcctgctttt ctgtgcggat actgtggggc atattatttt tcctcccaccactctgtaac 4380 tgagacccca gcatagtgct tcaacagaca tagggttcag gaggcttctgtcttctgttc 4440 aatttatttc aggtttcatg aagcagtttc atactgtaca atggacaagccttacaggtt 4500 caggaagtgg cctcatgttt aatgagcttt agctcattta tattcagagctgatacaacc 4560 tttctgagaa ttgagagtga ctgccaaagt cacctgggaa ggcaatgtcagttcaagcct 4620 taaacatgac ttctgccatg ggcaagcaat gtcagtgcag gcctgatacctccgtccctc 4680 actccttcaa ataccccaga ttttgcaagg ccatatctgc atccagaaaaggcagaggcc 4740 atgctcgggc agggagaggg ataataaata tttctggtgc ctccacttatcaggaaactt 4800 gatacccctt tgggcggctc cttggttccc ctaacatttt agctcgaactgtcagagtct 4860 cagcaatggt gtcacatgtg cccatcagtc catgtgtcac tggatggggcaggctaaccc 4920 ttcgtagctg agaagaggac atctcacact tcagaggtag gagggatcgaactggtctcc 4980 agcaaggcct ttgttcctgg ctgtgctcac tgagctgaag acttgggtagcacttggagc 5040 aagtggcagg aaccagaaat tgaatagttt tcatgatgct tgcctggttcagagattttt 5100 ttttgtagct ttcctccctc aagtctaatt ttgtcctttc tctttgttgcaatttacaga 5160 tacttggctg accaccaact taccggcatt gacagtaggt aaataatcctctcgcccctc 5220 cctagggctc actctctacc tctggacaaa cgtttctttt gaaaatgaaagaatgaggct 5280 caagctggcg cctctgtttt tcatgtttcc gcgagttgcc tggggaggtagactccctgg 5340 gaacctagtc ctgggtcaga tgttggaggc tggagggtgc tggtgacctgtctcccctgg 5400 gattctgttt tatgtagtca ggaaagatcc tcagccaggt gctcaggacaagccctggag 5460 ggctccctaa tcctactggg accttgttcc tggccctcag gccacaggctgcagacctgc 5520 gaatagtggg gaaagtgcct gtccccatag ctgtctggcc aatgtcctaccattcctggc 5580 actttgctag aagccagaga ggatcatgtg ggtgccacca aactcctgaacgtgaggcag 5640 gtcttggcct cctatctgga gctgtgcagc ttcatcctgt gtgagaatggagctcacaat 5700 gaggagtgag gcgtccattc ctgtcacctc cagtggggtc acaggtgcttccccaatact 5760 tgagcttcca tagacttggg tggagtagga catcactgct tcttccactatcatgaagct 5820 gaacctctgt ctgtattcat attcaaaggt gattacctgc acacgtgactttggccaatt 5880 aggaagtgcc ctgagtgtgg aacattcctt aaatccttga cctcataatcagtatggatg 5940 aagggttctt gtgttcccct gtaggatctg aatccagttt ggctctgaggctggtgaatg 6000 gaggtgacag gtgtcgaggc cgagtggagg tcctgtatcg aggctcctggggaaccgtgt 6060 gtgatgacag ctgggacacc aatgatgcca atgtggtctg caggcagctgggctgtggct 6120 gggccatgtc ggccccagga aatgcccggt ttggccaggg ctcaggacccattgtcctgg 6180 atgatgtgcg ctgctcaggg aatgagtcct acctgtggag ctgcccccacaaaggctggc 6240 tcacccacaa ctgtggccat cacgaagacg ctggtgtcat ctgctcaggtgggccttcaa 6300 gacctggggc tccctctctt ggggtggagt ttgctccaga agaaactcctaattacattc 6360 tgatctcctc actcaaagct tctcctgtgt ttcctgtgtt tttgaagacttgttagctct 6420 ctgctaagaa tccatatgaa ttcactgcct agtgttcctg tggtcacttaggacagggga 6480 ccaaactgaa acaacaaccc agactttatc cccttcctga ggcagtgcaaggaagaggca 6540 gaagaaaaaa tttctggctc cccagggctc catttctccc ctactgagtagcactgggtg 6600 agggtatggt ggacacagca cagacagcgg ggcagaggag ggatcctctccttaggagga 6660 ggctcatggt aaggaaagga catatgttgg ggtagggaat tctcacttgaggccccagta 6720 aggagcattt ggattggagg catatgggct aagagtgcaa acgggtatctgtgcatgtgt 6780 gacctgggtc ttggtcagtt tcagctcctt ccaaagaact gcagtgcattgtgtgtctag 6840 caagcatggt gttgggaggg cagctcccat gagatctgcc aggcaaagccttgttattac 6900 gtgtggtttg ggatggaaga tcacacaggg gatttttgct ggagtggtatcctgagactt 6960 gctgacttgg tgaattgcta aaacctgcaa gggaaagggt tggttttggttcaattggac 7020 atcacatcca gacacagagt taattgcctt ggagctggaa atggtggacagaatctgctt 7080 ggatccctta taaggagcgt ctttgaatcc agccaaagca ctagcattcagcaggtctgg 7140 gtgaaactcc tgggtcttgc ttgaagcctc tggccgctcc ctacctcaatcaatgtggta 7200 tctaccagtt gtcaattgat ctttaaagag gatctattat tagggatgcttttgtttgca 7260 catggcagga actcaactca aacactctta agctagaaag gaattcattgtctcagttat 7320 ccagaatgtt tagtggtgga tctggagctt caggtacagc tggttccagaagttccaagt 7380 cttttttccc catgctttgc ttacatctac tcttttatct gtgtgggcttcactatcaac 7440 ttgctttttg catgtggctg agagacagca gtgggcagcc ccaagtctatatcccaccag 7500 gagaaggagt cagtctgtcc cagtacctct ggctgacaag gcctgggaggactttgattg 7560 acctgcttgt aaacaggtgc tttcttccaa accatctcta ttagctctgacggctcagcc 7620 agagttctat acccatcttt gtgttccttt ggggcgacgg gaaggatgggggcactaggc 7680 tctacttgaa tcttgtagga tgctactttt taaaatagga atgactgtttctattagaat 7740 aaaaaacagg caggatgttt gtgacagaga tagccatccc tcagttggacccttcctttc 7800 ttttgatact atctgctctt tgctggttga cgttacccct ctatcctgagatggaacctt 7860 ccctctccct ggctgttgcc catgttcatt accatcatct ctatctagttccaggacttt 7920 ttcattatcc ccaactgaaa gctcttaccc cttaaccatt cataatccatttctctttcc 7980 ctcagcccct ggcaaccact aatctgcttt ctgcctctgt atacagattttactaagaat 8040 tgtggtcact ttctatgaat ggaatcatag ccttttctgt ctggcttcattcacttaaca 8100 taatgttttc aaggttcatt catattttag catgtgtcag aactccactacttttaactg 8160 ccaactaata ttccattgta tggctacgcc atctttgtct atccatttatcagcttatgg 8220 acatatgggt tgcttccatc ttttggctgt tgtgaataag tctgctatgagaattagtgt 8280 acggtttttt gtttgcactt gtgtttccaa ttttgggaga tatatacctaggagtgggat 8340 tgctcggtaa tagggtaatt atgtttaatt tattgtggaa acactgaacagttgccacag 8400 ctgctgcacc aaatttgcat tcccccaagc aatgcctgag aattctgattcctccgtatc 8460 ctcaccaaca cttgttatga tgtctttttc atcatggcca tcctagtgggtgtaaggtgg 8520 tatttcatgg tgttttgatt tgcatttcct tgatgactaa tgatgttgagcatcttttca 8580 tgtgttggtg ggccctttgt atatattctt gggagaacag gggcttcattttatagatac 8640 taagctgaag gccagaggaa ctagactaat gtcagtatct tagcccaggctcacaggaca 8700 gggttcaggt acacagaggg atcaggatgc ctggcccagt gttgtgtctagcatgtgaca 8760 ttccttcatg gaggcctaac tctgccattt tttctccatt ctcaggcataggcactgcta 8820 ggtatgcaca actaagtgtc ctcatagttg cttctgccca ctgtccctgtagctcatggt 8880 attcagtagg tccaggtttt gtttcagatt gaaggcaagc tgtgggtttgaaagtgactc 8940 aggaataagc ctcgggcctg atggggtggt ccctgtgagc agagtgagtcagccagaggt 9000 ggagaggtgg actctcccaa gaaccaggtc ctagggctgc accttgccaggcagctggga 9060 gctggtctcg gttgcatcct gctgcagggg cacttgagcc cagtggtccctgcagatcca 9120 tgctgatggc tcctgcactt taacctctga atctgaaggc ctggctcagcacttgaattg 9180 ctggtcactg gggtaactcc atcagagaac atgcacagct cagtccacacccaagggttc 9240 tagaaaacaa cccttaagtt gatgaagaac atcaacttaa aatgatgaagaacaggcttc 9300 cgtcaatgtc tatgctgctg gagaacatta actggagacc cagaaaccttggccttctgg 9360 aagaattctg aacttcactt gacctcagat cctcttcctt taggagatacaggagagagt 9420 taattttcct gtcttttcta gaatccaatt ctggtttggc cctgaggctggtgaatggag 9480 gtgaccagtg tcagggccag gtggaggtcc tgtaccaagt ctcctggggcaccgtgtatg 9540 atgacaccaa tgacgccaat gtggtctgca ggcagctggg ccgtggctgggccgtggcat 9600 tcccaggaaa tgcctggttt gatcagggct caggacccat tgtcctggatgatgtgtgct 9660 gctcagggaa tgagtcctaa ctgtggagct gcccgcacaa tggctggctctcccacagct 9720 gtcagcacag tgaagatgct gtgtcatctg ttcagatggg cctccaagaccttgggcctc 9780 tattttagtg tgtggttttc tccatgacaa ggcttctctt tgcactggcctcttcccagc 9840 ctgagcttct cttcaagatg gccagtttct ctgatacctc agcaaggcaataacctcagc 9900 aaatgttgtt ggcgtctttg aattttatgg gtaggcacta gcttctttcttatgtaggtt 9960 cctatagcaa acaagggttc aatctacttt caggctgtaa gaatgaattcttccaacatc 10020 tttttttgag actaaccgtt aaggtttata tctactattc cactctcctggatgactctt 10080 ggggagcatt tctaagtgat gagatgggga caggcactca gcatttctctcgctcatcat 10140 cctgggcact gggactgact catgttttct tcttttcctt gcagccacccaaataaattc 10200 tactacgaca ggtgagtctg ctacacccca gtccagcaat atttctcttgggaattccac 10260 cctctcttgt ttccagaagt aggaggagta gggtagactc cccctgggggggtaatttct 10320 ctctgaggac tctgatcttt gttagggtga cgagctgagt tcccactgccatcactctca 10380 tgtctggttc accgtggagg gcccctgtgg cctcctgcta ttgcctgctgatagtgctaa 10440 gtgctggcag agatgctgct gtggaaggag gctttggtcc tcccattatttcagatgaaa 10500 ataactgtct aaattaaccc atggaaaatt aggaccttca ttttagaaacatagccaagt 10560 aatacttctg cacgtatttg tcaaataaag aacactttca ctttgagggagccatccgca 10620 aagcgttttt gtgccacagt gaaaatatcc tgggccaaat atgttgggaggtgctacata 10680 ctctagacct tactggccat gaacagtgta aactggaatg gtcaaggctctgagaagtcc 10740 tgtactaagg aaaaggattt aactttgtca gtcaaacaaa ttactatggaatggaaaaat 10800 tatctactaa aatcctaaac agcttcattt ttttttctag attggtggcatccaacaact 10860 acaaccactg caagtaggta tcacattttc tacctgaacc ataggtcatacatttcttat 10920 ccccaagctt ggctatccat gagcgaatgc tctgccccac cccagccttcctcaatctgc 10980 acatagccct ggcctgtccc actataccct tcacctcttc atttgaatcaatgagataag 11040 tattcttaaa ataatagact taaaggcttt tattttgggg ggtatctccaaagctttagg 11100 aggaagaagg gagacaaata gtaaatggat aattttacta caaattatgcttttccatgt 11160 catttttatt tcaccatatg gctatgtttc aatagatttt cattgcttttaaaaaataat 11220 agggatactt ttctgtgtta ttaaatcttt tctcacaatc attttaagtccctgtattgt 11280 attctattat acagatatgc catgaattat ttgacaaatc atcagatgctagatatttgt 11340 ttgtatttct tcattactgt aaatgatttt gtgatgaaga atatttttatagataatttt 11400 tttgcatacc tcactaattt ttcctttagg atataaatgg gtttactggaccaaagtcaa 11460 tgtcattgta gtgcctggta catagaatgt acttcatgca tattaacttttactgtgtta 11520 ggtattttaa gatcttgctg tgtgtatggt caaactacca tcaagaatggttgtaaaatt 11580 atggaatgat gtaagagaca aactgatctt cttcctcaga gctcacaatattattttgta 11640 cacaacaaac tagaaaatta cagttgtgac aactgtttcc aaggaaaagttcagtgtgca 11700 aagaggaagt attagtagag atcttccttg attggggagt taggggaagttccttatgga 11760 agtgacattt aagctgggag ttaatagagg agcaggttca tttgctgaagtgtcttctaa 11820 ccagaaggga tgctttgaag gccctagggt gggaaggagc ttggctctttgaaggagggt 11880 ggggtgcggg caaggaggga ctgcaggaaa tctgtcgggt gaggccagatcattcagggc 11940 cttgtgggtg ggttaagact cccatcttta tcctaaaggt agggaggctgcagaaagatt 12000 ttaatcttga gaattagcta attggaaata tatttgcaaa agatcatgtttatcttttct 12060 gccaaactgc atttcctgaa ggcaggggcc atgtctgcct ttttcataatgtatccttat 12120 tatctagcat tgtgtctgcc tttcaagaac tgtttattga aggaataaatgagtgaatga 12180 atgaatggat aaattaatga ataaatacat aattactgtt ggcattttggcatacattcc 12240 atacactgta tacacacaca caaacacaca cacacacaca gtatggcatgctttatatcc 12300 cattgtataa tccatcattt tcatttaagt gtatataata cttttttcatgaccttaaaa 12360 ttagcatttt tataacattg aaattatttg tatagaagaa ggtttaatgactatatgatt 12420 ttccactgta tagatatatc atcatttagt taaacggtta ctaattgtggggcaaaaaca 12480 ttgtttccaa ttatatttta taatgttaag tgactatata caatagcatattttataacc 12540 atttatattt aatgattaga aatatgtaac tcgtatcctt gtctctgaaagtttgacttt 12600 atccttaatt atttcccagt gtagaaatag aaagggaggg caggccacatgatcttcaag 12660 aaacactgtc ttcccatcaa atgggagaac gtatttctat ctcataagggacttgtatct 12720 aggatatata agtgactctt gtagtcaatg ataaaaagtc aaataacccaactgaacaat 12780 gagcaaaaga cctgaaagat atttctctac agaagattca cagatagcagagaaggcatt 12840 ggaaagatgc tcaatgtcat tagccgtcag ggacatgcaa atgaaacacccagtaggtgg 12900 gctgtagtca aaaagccaga taatagcaag tgttgatgag gatgtggagaaattggaaac 12960 cttatgcacg gctgcaggga atgtaaaatg gtacagccac tttgagaagcagtttggtgg 13020 ctcctcgaaa ggttagacct ggagtcacca tatgacccag cagttgtattcctaggcata 13080 tacccaggag aaatgaaaac atatgtccat acagaaactt gtatgtgaatgttcaggaca 13140 gctttattca tagtagccaa atgtgaatgc aatgcaaatg tccatcatggtgaatcgaga 13200 aacaaatatg atatgtccat gcagtggagt attatttggc aataaaaatgaatttaatag 13260 tggccgggcg cggtggctca tacctgtaat cccagcattt tgggaggccaagatgggcgg 13320 attggctgag gtcaggactt cgagaccagc ctggacaacg tggtgaaaccctgtctctac 13380 taaaaataca aaaattagct gggcatagtg gtgggcggct gtaatcccagctacttggga 13440 agctggggca ggagaatcgc ttgaacccgg gaagcggagg ttgcagtaagctgagatcgt 13500 gccactgcac tccagcctgg gtgacaagag cgaaactcca tctcaaaacaaaacaaaaga 13560 aaaaaaagaa tttaatattg atttatgcta caacatgatg aactttgaaaacacattgag 13620 aagtcagtca aaaaaactac catattgtac aatttgtttt atatgaaatgtccacaatag 13680 gcaaatctat agagacagaa aagtagatca gtgggtgcca ggaatggagggtgttgagaa 13740 gaaatgggga gtgattgcta atgagtacag ggtttctttt tggggtgatgaaaataatct 13800 aaaattgact gtggtgattt cagagctctc agtatgctaa aaaccatggacttatcccct 13860 tagaaaaagt aaagaaagag ttatgaaaaa gaaaaaaaaa gacgttttaatttctatcac 13920 tgagtgtgca catgttttta aaaagttttt attactataa accaaccaacaaaatgtttg 13980 accacttaat atttatcctt ttctgataaa taacaatagc taatattgctgggtgcttat 14040 gtgcctggca ctctctaaga gtttatatag acatagaaac ctatcttatgtttatgtata 14100 aatgttcata tatacatatc ttatttaata ccctcatcag acagatgaggcagatgccat 14160 taccactctc atttttctga tgaggaaact gaggcagaga ggttaagtaactggctccag 14220 atcatggagc tgatagaggc agagccaaga tgcaaaccca ggcttcttgttgcagaaacc 14280 ctgctcctaa cccaacgttg tgctacttgt gaattggcag agtcctgtgctcatggaaga 14340 cgctagggaa cacactgtgt tatggagtgc tctccacggg tcagcactgtgttcagccag 14400 gactatccca cgtccctgtc tgtagctgat tgaacaatga tagctgtcactttgttgctt 14460 tcttggcatt tttgctagag gtgacacatg ctccctctga agcttgggtcacctcctcgc 14520 agagggttgc tgtccaggcc taacagggaa agcagggact tgaatcaaagcttctaatgt 14580 tgggccacct agaaccaggc ccaagagagg ggacttgttt acagggaaagttaagtcttg 14640 ttataaagtg cagaagatga aactggatga tacttacaca gatgattccttgtcacaaaa 14700 tacctgaaga cctggtacaa tggagatgtc ccctctctcc tctctaggaccctcttcaaa 14760 ttgtggtggc ttcttattct atgccagtgg gacattctcc agcccatcctaccctgcata 14820 ctaccccaac aatgctaagt gtgtttggga aatagaagtg aattctggttatcgcataaa 14880 cctgggcttc agtaatctga agtaagtaat gcctggtcat ctggtgaggggtgagttcct 14940 ctgcagcaca cccactggtt tagactgtgt cctgggctgg gatgcttttcactctcatgt 15000 gccatggaca agcttttggt ggctttgatt cctaccataa agcatcagggaacactgatg 15060 tcctttgact taattgagga agagctagaa gaaaaacctg tattcaatggcatccctcgt 15120 aaagtgcaaa ctatttataa aatggagggg caataggaat ttcaatgttgacttgaatac 15180 attttctcca tacagattgg aggcacacca taactgcagt tttgattatgttgaaatctt 15240 tgatggatca ttgaatagca gtctcctgct ggggaaaatc tgtaatgataccaggcaaat 15300 atttacatct tcttacaacc gaatgaccat tcactttcga agtgacatcagtttccaaaa 15360 cactggcttt ttggcttggt ataactcctt cccaagcggt aagtgcacactagaccatgc 15420 ctatgaggct tggtggattt acccagctgc ctctttgggg gcaccatggttccccaagga 15480 aatcaaagaa gggcctcagc gatgcacggc ccattctctt tctcttggcactgactgtgt 15540 gggcaggccc ttgggaaggc agcaaagggt gcagactggg ggttccacctggccttgggt 15600 ctgccaccaa ctctccaggg gacctggtga ctctccttca gagccacccctctccgtctg 15660 gaggtgaggg gatctgagct tggcgatgtc tagagcccct ttcagctctgcatggagcgg 15720 tccagtacct ccaccccagc ttttccacat ttctatttgg cgactttagaggtgggaaaa 15780 ggcctgtggg atgcttggcc tttgaggttt gttgtgggac atttgttgtgggacatggcc 15840 atgatctctc agttaatgtg tctttcagat gccaccttga ggttggtcaatttaaattca 15900 tcctatggtc tatgtgccgg gcgtgtagaa atttaccatg gtggcacctgggggacagtt 15960 tgtgatgact cctggaccat tcaggaagct gaggtggtct gcagacagctagggtgtgga 16020 cgtgcagttt cagcccttgg aaatgcatat tttggctctg gctctggccccatcaccctg 16080 gacgatgtag agtgctcagg gacggaatcc actctctggc agtgccggaaccgaggctgg 16140 ttctcccaca actgtaatca tcgtgaagat gctggtgtca tctgctcaggtatggcccaa 16200 tgccatggaa ggcccatttc acctgtaact tgctataaag caagagcttaaggccagtgg 16260 ctgatggtgt ctgtggccca ggcaggagct ggtcattgtg tcctcgtggcctgcgcactc 16320 cagaagagca tgcagggggc tgctttatct ttggccagtt tctggacccagggccattat 16380 gctgaacact catctgacta aaggacctcc agcaatgatt ttacttctttatgcttcagt 16440 ttccttgact gttgagtcgg ggtggctatg acagtacttg ctactggtgacaattgggat 16500 ggttttagaa caatcatggt caaggagaga gtgatgggtg ttatgacctcagctgtaatc 16560 ctgatgacca caagtatgac gggacttagg gagcatctgg ggaagctgggaaggcttctc 16620 aatagcaatt gctgggtgga cctggggacc ctcgccgagg ggggtcaggttatgggccat 16680 gtaagtgtat ctctgtctca ttccggcccc tcctccaagc cacatgtctgtgacctatgc 16740 tttttttcta ttcctttttc aggaaaccat ctatcgacac ctggtaagtccctccgattt 16800 ccattccact tccctggtct ccaggtctct ccattactgc tgcctagactgtgcagggca 16860 tgttgctcac tctccaagga gttcatctgt ggtaccatcc tctacagcccctgtcccctc 16920 ccctgccggc caccaggata gtgtgcccct ctctgtgctt cagtggcctgacccacctaa 16980 gattaggatc tccagtcagt cccgaggtga ggcccgccac ctgtcagatttgactgtcct 17040 cacagacacc agaccctgac cagtgttggc caaatggggc ccactgcatcgcagagctcc 17100 tccctgcctg cccctgagct gctctgagtg ttcccagcat ggccctggcacctctccaac 17160 accccccact gccccgcccc ctgcttgctt tgtcatcccc tcctggcctcccatagcagc 17220 agcttcaggc ctgtgccctc ccatccattc tacactgtgc agccccttcaagagattcct 17280 cagggtcttc tggtgatgac cccgctcctc agcacagcat gactgccagggctccccatg 17340 atctgctccc tatgcttggt gccctctccc catcctctgc ctgctccatctacacggagg 17400 ttcccaaatc tattccaccc aggtgcagtt gcacctgctg ttcctctgcctgggacaccc 17460 cgtttctacc tctttgcctg ccccctaatt actgcccttt tttccccactccatctgggg 17520 caggggccag acttccaggc tcctctcctt ccccaggctt tggtcaatctcatccttttc 17580 ccagtgtgct gggattcgct ctcctccaga cctccccaaa ggcaagtgagctccccaagg 17640 gcaaggcctg tgtccagctc ctccctgtgg actcaggctt ggcacagcatctgcacagct 17700 catgagcagt agacagctgt gtcagggatg ccagaaaact gatcctgatcttttcttttt 17760 gtcaacagct ccttttctca acatcacccg tccaaacagt aagttctgagctccctgaca 17820 agtctgtggc agagtggcct ggaaattccc cttcccattt cctcagtgacaatggggctg 17880 gggaggagat ggcttccccc aaagtggtct ccctgcaaga gtgccctgccagccctcagt 17940 ggacggtcca gatctaggcc acctcttgct cttacttggt ttctgtcttgggaattattt 18000 tataaaattt taaagtaatt taaatttaaa gtagtccgca ggtagactgtgcagtgtgct 18060 ctgggggtca ccgacattcc cactttttgt cctgacagca gattattcctgcggaggctt 18120 cctatcccaa ccatcagggg acttttccag cccattctat cccgggaactatccaaacaa 18180 tgccaagtgt gtgtgggaca ttgaggtgca aaacaactac cgtgtgactgtgatcttcag 18240 agatgtccag taagtgtgcg cccagaagaa tgccttgggg ccccacagacctttcaagag 18300 ggaataaatg gtgcttaagt gtgcgcccag aagaatgcct tggggccccacagacctttc 18360 aagagggaat aaatggtgct tagaaagcca ggagagaagt ttgctgagagacatttttga 18420 cctagcccag aggcatcccg tggagagttg gggagggggc acgagagccttggagtggac 18480 aaaagctctg gtttcaagtc ctaggtcttt caccaatttg ctgtgtgaccacaggaagtc 18540 actcaacttt cctgagcctc agtcaaaaga ggggaataaa atacctgctttcctcacctc 18600 actgtttact gggaaggtca cgagaaacag agaggagaga gagggagagagatgtgaaaa 18660 tatttacaaa atgttgtcca gtggaaaaga tggttgttaa gtagtaatgatagacttagg 18720 ggcaataata gcactaataa tcctattaac aaccacactg gccaggtatgctgcctcagg 18780 gttgtaatcc caacactttg ggaggccgag gcaggaggat cacctgaatgcaggagttca 18840 agaccagcct gagcaatata gggagacccc ctatctctac aaaaaagtacaaaaattagc 18900 tgggtgtggt ggcctgcacc tgtagtccca gctactaagg aggctgaggtgggagaatcg 18960 ctagagccct gggagttgaa ggttgtggtg aactatgata gcgccagtgcactccagctt 19020 gtggaacaaa acgagaccct gtctcaggaa aacaaaacaa aacaaaaagaacaattgtat 19080 ctgttttgtg gaaccctttt tctccaccca ttcctttctt catgtgagttccccaggggt 19140 cgggcagaga tggaggaatt gctgctccag agggtagggt atctgctctgcatccaatca 19200 taagtagaaa tcatcgtttt aagcagagag gacattacta aaagcacttttctttctttc 19260 tttctttctt tctttctttc tttttctttc tttctttctt tctttctttctttctttctt 19320 ttctttcttt ctctctctct ctctctcttc tctctctctc tctctctctctctctctctc 19380 tctctttctc tctctttctt tctttctttt tttttccgga catggagtctcgctctgtca 19440 cccaggctgg aatgtagtgg cacggtctcg gctcactgca acctctgcctcccgggttca 19500 agcgattctc ctgcctcagc ctttcaagta gctgggctta caggcacacgccacaatgcc 19560 tggctaattt ttgtattttt attagagacg gggtttcacc atattggtcaggctggtctt 19620 caactcctgg cctcaggtta tcctcccacc tcggcctccc aaagtgctgggattacaggt 19680 gtgagccacc atgcctgatg tcaaaagtac attaatatat gatttatccaaggaggcggg 19740 tggcccagct aactgtgaag aggcaccagt gtttgctagt gtcctgaacaaggggctaca 19800 ctaatttctt ctctaacagc cactgttgaa caaaatagtt ttccctgttgatttctgttt 19860 gcagtgggct ttggagtctc tgctttagtg attcatttgg gattttgcaaaagatacatc 19920 attttattct ctttgtcatt acaatacaaa gattgcactt aaagctgatgcagtcctatg 19980 ggaaaaggtt gaccatgact ggttctttaa ccagcatctt gatagcaatgaccatcacca 20040 tttgtgacat tttacaaagc ccttttctgt atgttgtttt atttgagcttcaccatagcc 20100 ctcttcagtg tgcatggatc agattacttt gcctttgtaa ataggaaaagctttagagag 20160 attatttgac ttgcccagta tttatttatt caattattta tttctctcactatgaattca 20220 tgcatattga ttttattctg tgggggcact agggactttt cgatggaagaaaaatggtct 20280 aaatcaggat gcgagccctt cctttcctga tgtaaagggc tgacaggtgaggggctgtag 20340 atttcatatg tgtgattgca aagggcagga ctaagaccca ggcatggaggttgagggaag 20400 atgagactct cttgatttaa ggatacctat gactttcttt tgtttaaatttttatttttc 20460 tttttatttt ttgagacagg gcctcactct gtcgcccaaa ctggagtgcagtggcacgat 20520 ctcggctcac tgcaacctct gcctccttgg ttcaagtgat tttcctgcctcagcctcctg 20580 agtagcctcc ctcaccctac aggcttgtgc caccacgccc ggctaatttttggattttta 20640 gtagagacag ggtttcacca cgttggccag gctggtctcg aacttatgacctcagatgat 20700 ccacctgcct tggtctccca aagtgctggg attataagtg tgagctactgcgcccagcca 20760 aggagaccta tgactttcat cgatgaactt tgtcagagtt tctggcacagaggtgtgacc 20820 ccaccctgag atctgacccc ctgcgtcaaa ttctgggagg aaatgaagccaaatggtgtg 20880 tcctctctct gcaggcttga aggtggctgc aactatgatt atattgaagttttcgatggc 20940 ccctaccgca gttcccctct cattgctcga gtttgtgatg gggccagaggctccttcact 21000 tcttcctcca acttcatgtc cattcgcttc atcagtgacc acagcatcacaaggagaggg 21060 ttccgggctg agtactactc cagtccctcc aatgacagca ccagtaagtccccttgtgga 21120 aatgctctgt tgggactggg gacatcctga gagcatctgt ggctcaactgtcctgttgtt 21180 gtgaaataag aaatgaagga accctttcag gtcaccaggg cttgattttcagctgaaagg 21240 gaccaggagc agtgggactt gggactctgg ctgcccagaa ataaagtcagggctagaact 21300 ggctgatggg tgatgattgg tcttactgtg gtcagcagag actaagtagagggtccagat 21360 gatgctcttc gtggagagtg atgagtcagt gccaaaggca gaggtgacctcttggcttga 21420 aaccttgtga ccttctcaga gtgtgggaca ctgtggccat ggcctgagacctaacacatt 21480 tggtttctat ctgaagatgg actgagctgg gtggctggaa gtggctgagataaggtcact 21540 cagacacttc cagcagagcc tgtatggcca tgatttgagt tgctgtatggactgatatgt 21600 agaatggcca agggccaggc aaggtgacat ccagggtctc ttatgcagtcaggattaaag 21660 actgacttgc ttcatggcta aaagaccttg tttcatgaca ttcccacaatttgatcatac 21720 agttacttta ctttatagat aaatggtaac ttggccaaac ataccacttatttaaaaatc 21780 ctgcctccaa ttctccatca gagaaatcct gagtccacgt gctctccttgggctttcata 21840 aggatggggc tgacttgacc ctcgggtcct tgggggattg cagtgaggtctatgcccaca 21900 tcctaagtgc tgaccctccc tgtcagccac cctggtctgt gcactttttaagtggaaaca 21960 gcctctggcc ccgtaggact tgtggagtct ggggcagtga ctgagtgccttatctgtcct 22020 tgtctatcag acctgctctg tctgccaaat cacatgcaag ccagtgtgagcaggagctat 22080 ctccaatcct tgggcttttc tgccagtgac cttgtcattt ccacctggaatggatactac 22140 gagtgtcggc cccagataac gccgaacctg gtgatattca caattccctactcaggctgc 22200 ggcaccttca agcaggtaag cctggggctt cccattccat ttcccagtgcacaagctttc 22260 ttagagcggt atgtcctgtg cttcttgaat tctggggatg aagaaattatgattttggga 22320 taatcaggac ataattggaa taaaggaaga taaaaaacct ttggtgctatgatatggctg 22380 cagctacttc caaataggaa gaaggaagct gagcagaaag agtatctcccgctgtgtcca 22440 gcagagaggg cttctggcag accgccactc ccatcagcaa taacaacagcagctcctgga 22500 gcaggtccag attttgcagg gcctgaagat tatacagtta gggttgggggtgagaggcag 22560 gtgttgagat gggcaggggc ctcattaagt caaagaatgc aatatctatgaacttttata 22620 aactttgcaa aaacgtatgg ctgtgcaaac acattgctag gccttggaggaggcctgcac 22680 attgcagtag gcagggaaga gggggcccaa aagcttcagc ttcattagctccatagtcag 22740 ctggcctctg cagctaccat ttgttgagct atcaccatct aagatggccccctgcatcca 22800 attttgggtg aaagtgaagc caatatggtg tgtcccttct ctacaggcttgaaggtggct 22860 gcaactatga ttatactgaa gttttcaaca gcccctacca ccgatttctgtggtttgcct 22920 gggactttgc agattttagc atagaaagtc ccacgttcca ggaaacccctcactcccagg 22980 caaatgagga cggttagtca ccctacaagt ggcagatgct gtgattggtccttgtcatac 23040 tcccccagtg aaggcctggc cttaattgtg ttgggttctg gcttgctgtgagtttggtca 23100 gtggaagtca gtccactgaa ggtgaccatt gttcctatgc caagtgagcagcctggagac 23160 tccctgagcg gccccgctga gggcccttca cacccattca cacccattcacactcgttca 23220 cacccattca cacccgtttg gagcggccag acaactctgt cagccctgtttcttctaact 23280 tggctgatca tgaatagcac acgccacatt cttattcctc cactcatttatttattttta 23340 ttttatttta attttttaat gacaggttct cattctgttg cccaggctggatgcccaggc 23400 aggggtgcat catagctcac agcagacttg aactcctggg cttaagcgatcttccagcct 23460 cagcctccag agtagctggg actataggca tgcaccacca cacccagctaattaacaaat 23520 ttttttttgt agaggtggga tcttgctatg tgtcccaggc tgatctcgaactcctgagct 23580 caagtgatcc tcctgccttg gcctcccaaa tgctgggatt atgggcatgaaccactgctc 23640 ctggcctcct ctatttcttt aaataaccat attgcctatc acactgagtgcctcaggggc 23700 agggccaatg ttttgttcat ctttgcaacc cccagtgccc ctggtcctgagcctaagagt 23760 tgatatagta ttattaacag ctcatacaga tatcagacac tgaactaagtgtgctatata 23820 acttttaaaa ttctcaggac aactttattc ccacttaatt atgaggcaacggaggcttgc 23880 agaaggtaag ccacttgccc agaaccatat ggccatgagc tgcgggtctaagacacagaa 23940 gtagggctgt gccatccatg gctggagctt cccacagctc caccaggctggcctgtgata 24000 gtgaattttt atctaaaatt agaactgctt cttctgacca agaaataaatctgcactcca 24060 tgttcattat ttggagtgga ttcagaattt acctccatcg taggcaccacaggcaaatgt 24120 gacatccatg caaatgatca tgttaatgta cagggttcaa tggaaagcacttgagagcat 24180 ctttgaaaga gtaagaaggg tcatactgtc atgtgcgtcc gtgtgaaaagaccaccaaac 24240 aagctttgtg tgagcaataa agctttttaa ttacctgggt gcaggtgggctgagtccaaa 24300 aagagagtca gcgaagagag ataggggtgg ggccgtttta taggatttgggtaggtagtg 24360 gaaaattaca gtcaaagggg gttgttctct ggcgggcagg ggcgggggtcacaaggtgct 24420 cagtggggga gcttctgagc caggagaagg aatttcacaa ggtaacgtcatcagttaagg 24480 caggaaccag ccatttttac ttgttttgtg attcttcagt tacttcaggccatctggatg 24540 tatatgtgca ggcttgggct cagaggcctg acaaaagggt ttattgcggtcgtatggttt 24600 aagtcatacg gtttattgtg acaactgttg gcactgaaat ataaagcaaaaacaaatttt 24660 taagacagtt taaagtcaga aaatgtacgc taagagcagg tggacaaggtagaacccctt 24720 cctgtgggtc ttccccagac ctggacccag agtgtaagct ctggcaccctgtgctggctc 24780 atagccaaag gataggcacg tgccatggcc atctctgagt ggttctgggaggggtggaag 24840 tcttgttgag tcatgtccct ctcattcaca cccaaatcag ctatgggattcccttagcag 24900 gtgacatgtg cctgactctg ctctcttgcc tgcctctcct aggcagacaatgacaccatc 24960 gactattcca acttcctcac agcagctgtc tcaggtggca tcatcaagaggaggacagac 25020 ctccgtattc acgtcagctg cagaatgctt cagaacacct gggtcgacaccatgtacatt 25080 gctaatgaca ccatccacgt tgctaataac accatccagg tcgaggaagtccagtatggc 25140 aattttgacg tgaacatttc cttttatact tcctcatctt tcttgtatcctgtgaccagc 25200 cgcccttact acgtggacct gaaccaggac ttgtacgttc aggctgaaatcctccattct 25260 gatgctgtac tgaccttgtt tgtggacacc tgcgtggcat caccatactccaatgacttc 25320 acgtctttga cttatgatct aatccggagt gggtaaggag tgtctttatgctatggcctt 25380 aaacctttac ttgataactc aaacatgagt agccccaaag gcttgaagaatgcaaatttt 25440 gatgaactgc agttcccagt acttccagct taactggatc cctttctacatgtagtgatg 25500 tcctgtagct ttcacctttg aggtgctttt actctgtgtt ctgtatcacatccctgattt 25560 ctcatcaggt aggatgacca tgtatcatct ccagttaaca tctggggagatgggtgtctg 25620 gagaatagaa cagctcagca gtgttcactc agcaggttag ctgtaaactgtgatcagact 25680 ctaggtgact gaactccagc catacggtta aaaagacctg cgtatagtgggaaaagcatt 25740 gatttggagc agaccaaggt tgaaatgcca gctctgccac gtgccagttgcatgattctg 25800 ggccagtgaa agcacctcta tggaccagtt gctcgcctgt caagtggggataatgacacg 25860 cacatcataa ggctgttggg aggatggaat gagagagagt ggatgtggcactgagcacag 25920 agagtgtgcg gcaggtggtc caccaggaat gtgcactgaa gatggcaggagccctgctgc 25980 cctccttcag cctgggaata gaagctctgg gagtccatgg gttccagtcaagctcaggag 26040 gtgcagaggt caggccagag atgtcaggct ggggccagag ggtgtgcaggctgggctgct 26100 ctaccatagc ccagcttccc tggatgactg catgtgggtg aagtggggtttgactcttct 26160 gcactcatga tgacaccatg atgtgcaact ccagccccct ctgaagtctctgttgatgga 26220 tgtgtaccac acttcttggc ttacaatata gacctggaca cttcagtagccattgccttc 26280 caagagaatt tataccaata ggataaagag ttctactagg aattagaggtgggcagattc 26340 aattcgacac cctcttgata tgctaaacgt agcacctctt tccaggcacagtgtgaacat 26400 atgtcagttc agtaggtagg tgttgaggct caccttgttt acagtctatgcagcttgctc 26460 aattcacagc agcccccttg gtggctgaga ggaggggaga aagcttaaccagattcccgt 26520 tgtacaaata gtcataaggt gacttttgaa tttgtgtgaa ttgattgacattaatgaaaa 26580 tgagtgggtg accttagttc ttccttgcca aaggattctt tctggtcaaatcctgccatt 26640 tctatatgac aatgcaattt gctgggaaga cggggatgtg tgtgcaggggtagatgtacc 26700 ctggctatac ctggagcaca gggacttatt ggctacacct ggccatcaacaagatcatcc 26760 acctggaagt ccattagaat gacctggggc tccaaacaca ccctgcccaggccctacccg 26820 tacattctct gtttggcctg gtggggcttg ggcatgttac gtttaaaaaatcttgagtga 26880 ttctgaggtg gagtcatggc tgtggcttcg ctgtggcatt ctggtctgcgtggagccctg 26940 aatggcaggg ttttacggca aatgcaatga ctgcccaggg gcttctaagtgaccctgacc 27000 tttttcccaa gtgtcccacc tctgaacaag cctctggcta tttttgcttcctcctttgcc 27060 actaagggag ctactgtgaa aaaaaaaaac aaaaacaaaa aacaaaacttggtatttgag 27120 agaatctggg ttgcctatgg aggaaggaag gaggctctag aagacagaaggaggggagca 27180 gatcctggcc aggttcccag gctgagccag actgccctgg agaccacatccaccacccac 27240 gagaaatgcc catcctaggc cagtgggcca gttttcctgg cttttctctttgccatgccc 27300 ttcaaaatcc caccaatcta taataactgg gttagtgtga gctgcttcttccatcttagg 27360 aaaattcctg taagcatatc cttaggttat tttccctctg acccctgctgagaggaggtg 27420 ccccagggaa tgaggagggg gtttatatcg gtataggggc tcctggagggttcgcaggcc 27480 agtgtggaac gtacagctgc atggggctca gggcaggctg aggagggtcaggaaagagag 27540 gccctgggag agggagggtc agggcactgt actcagagtg cagccgaatgagaccttgcc 27600 tggccctgac accaggtgag agaagggaag gtcatttact tttctgccctgtctctgggt 27660 cccgctcctg ggctccaaac tccagctact tccctgactc atctggtttacctgggtgca 27720 tggagcatgt ggtcattgtg ggattaggcc tcaacccact gtgcagtatgggacctgctt 27780 gtctattggg aaagccctcg caggctttgc tgcctaagga tggcggtgaggtaccggagc 27840 tgccaggatt tctctgcagg cccctcagtg agtgtctgat ccacacgttctgacagaagg 27900 aaggtgaggt gtgcaggagg caggggcagt gaggacaggc tgtggagttcctcacctggt 27960 acaactgagt catgaaggaa gaatcgggcc ttggtgagag ctaaggggctactgttctct 28020 tccagatgcg tgagggatga cacctacgga ccctactcct cgccgtctcttcgcattgcc 28080 cgcttccggt tcagggcctt ccacttcctg aaccgcttcc cctccgtgtacctgcgttgt 28140 aaaatggtgg tgtgcagagc gtatgacccc tcttcccgct gctaccgaggctgtgtgttg 28200 aggtcgaaga gggatgtggg ctcctaccag gaaaaggtgg acgtcgtcctgggtcccatc 28260 cagctgcaga cccccccacg ccgagaagag gagcctcggt aggtggtcgctctcagaccc 28320 cactgtccac cagggcgcag acccctgact cggggacttg ggatgttcctcttggtgtca 28380 tattccaact cagattgagc cctacattgt gctgcacctg gtcatacggagttgaatcag 28440 acctggttcc cgcctccccc aaggctcatg gtccttggag gacccgttgcagggcgaggt 28500 caagagagtt ctgacctgga tggcccatag acctgacgtc ccagaatccatgcttctcat 28560 ctgcaaaatg aaaatgtcaa tacttacttc ttagcactgt tgagagggttacttacataa 28620 aggaattttg gtgaaactgc ctcagcctgt tcctggtgca agtcatttgagtgcttggta 28680 aatggtactt tttgttactc ctgttgttgt cacccctgtt 28720 <210>SEQ ID NO 8 <211> LENGTH: 3166 <212> TYPE: DNA <213> ORGANISM: Homosapiens <400> SEQUENCE: 8 tcttcctctc ctcctctgcc aggctctgtc ctggtgccctgtctgttatt gtggtctcct 60 ctccttccca gacgtgttgg tggctgatgt ggaggagacagccagcaccc aggggaggta 120 tcacagcact gccatctctt ctggggtctt cctggctgtggttctggttg tggcagcctt 180 caccctgggg aggaaggcac acagcaccag tggccggcctctgagctcct agatatgaag 240 cccagagaag gtgtttagat attggctctg ccagcccaggcacccgagag aggatggaag 300 aaacaagggt gcagagcttg gcgcccagca gcacctgaactccatttagc ttggcacagg 360 tgtatggtgg ggtgggtgga ggtggggtga agaaagatggggtgggtaga ggtggggtga 420 agaaaggtgg agcgaggttt tccccagatc cgaaggctcagtgctgggtc aaaatgtcaa 480 aggtaaacag gtgctaacgt ctaaagcctc acctgcaactctaagccaaa cattagtaac 540 agcagagctt tctctaggtg gaatttctga gccttttttttttttttttt ttgagacagt 600 gtcttgcttt gttgcccagg cttgagtgca gtggcacaatctcaactcac tgcaacctcc 660 gtctcccggg ttcaagcgat tcttctgcct cagcctccctagtagctaag attacagaca 720 ggctagacca tgcccagcta agttttgtat ttttagtagagacggggttt catcatgttg 780 gccaggctgg tctcaaactc ctgacttcaa gtgatctgcctgcctaggcc tcccaaagtg 840 ccgggattac aggtgtgagc cactgcaccc ggcctcttttctgacctttt ataagctcgc 900 ttcttaggcc tgtagcataa atctcagcct ttccttagggtagagccagc tgaataaaga 960 acctttttca gagtaagtgt caatttggcc actgttgccttcgtttcccc taagaactag 1020 atcctttcaa attaagcaga caggtggggt ggttgtcatacagaatgaga aggggcaact 1080 cgtgtgtctt cccagtgtcc ttggagtgtt ggttcttcccaaagcaggat atgcaggatg 1140 cagcctggag aaagacaaga atgctaaatg cattgtaagtttcagtggct gtgattgaaa 1200 attaaagatg attgcctcca tttctctagg gatctgcctcttttggtttt tgacacttca 1260 tctccagaac tatgggctgg ggcggttcag ggaaagaagcaaactcctta gggcccttag 1320 gaagggagtc ctgtttgcat gaggtctcca gagagaaggagattgacagg tgacccaagg 1380 agctcagaag aaacaaaggg atgagctggg ttccaaggaagcagtacatt tgcctagaaa 1440 atcagagaga aatcaggctc agggctccta ggtcaggcttggcaggaatg ggagcttttg 1500 tgtactgccc tggcaatgcc agtgtttgcc ccatgaagccaatctcagga cccctgtccc 1560 aagaggggac agctaagaca gcctaactct ggatgtgtgagttgagctgc atgagacccc 1620 agcagggcaa tggctacagg ggaaacccca ggacaaggggacagagaatt ccagcagaga 1680 cttggccata gctgccagct ctgactaggg ctgcccaagagctgcccacc accggcagct 1740 gtggtgagac gccatgagcc tccgtgggat tcagagtgcgtcctgagccc taccaggagt 1800 cagaggagct agggggcccc agggactgtc tcttgttggtttccattctc cttgccatca 1860 cccccaacac tcacccttaa cctcccaggc tggggcagttaaggaaagcc ttaagggttc 1920 ccctgtgacc atgagtctgc cctgaaaagc aatgtcaatgcagtggaatg caggcaccag 1980 cccaggactg gatctgagca gatgcagaag cagcaggaagctggagtggt gtgcgggttt 2040 gaggtacaca tcaatcagag taacaaagtg gcaagtcagacatccgagaa ttcaaaaaag 2100 ttcagaggct gggaacccaa catggaatcc caactccatccattcattcg ttcgttcatt 2160 cattcattca ttcattcatt cattcgttca ttcactcattcatgaatgtc taagttgtac 2220 cctgtgcttg agaaggagca gtggaggctg tgggtccctgctgtgaggat gagggggacc 2280 ctggggctgg gggctcagca ggcttgccct gagtggtccccatgagcgcc agccccaagc 2340 caggctctgt acttgaacct gtggatacaa agaggggtcatgcaggggtc accattataa 2400 ggggaaattt atttccacag gaaacatttc cacctcctgaagtgtcccct ctccttaaaa 2460 atagccccag tagccagtgc ttcttcgcag ataaccaccacagtgttagc cacttggcag 2520 cctctcaagg aaggaggtaa tggccccttt atcagcagggcccagccagg agagtggcta 2580 gtagggacag atgagtttgg tagcaagagg cagtgaggtccaggtgaaag gtagagcaga 2640 agacagggcc accggtgaca ggggctctgg actaaagctgtcagagtgtg actgagggtc 2700 cagtcacagg ggacacagag aagtgggctt gcttgggagcagggacccat cctccccatc 2760 cacaccacat ctccacactc agggaggatt gggctgacaccaagtggctg tgattcccag 2820 caactgagac tgtggtttga ggcaagggtg ctcaactctactgcacgtga gaatggcccg 2880 ggggcttttg aacctgctgc tgccaggctg cacccaagccagttagatca gaatctaatc 2940 agagggcagg cctggacatt ggtgacccac cagactcaggttgttccaag attgagagct 3000 gctggtttag gactccttaa atccctctga gagagtccaggttgtgccct gtgcttaaga 3060 aggagcagtg gagactatgg gtccctgctg tgaggatgagggggaccctg gtgcggggtt 3120 ctcagcaggc ttgccctgag tgttcctgaa agatctactttccaag 3166 <210> SEQ ID NO 9 <211> LENGTH: 18 <212> TYPE: DNA <213>ORGANISM: Homo sapiens <400> SEQUENCE: 9 gtggtctgca ggcagctg 18 <210>SEQ ID NO 10 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Homosapiens <400> SEQUENCE: 10 aggccagata cttggctgac 20 <210> SEQ ID NO 11<211> LENGTH: 22 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400>SEQUENCE: 11 cttcagatta ctgaagccca gg 22 <210> SEQ ID NO 12 <211>LENGTH: 22 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <400> SEQUENCE:12 tgcacatctc tgaagaccac ag 22

What is claimed is:
 1. A protein comprising a Scavenger ReceptorCysteine Rich domain, wherein the protein comprises the amino acidsequence of SEQ ID NO:
 1. 2. A protein comprising a Scavenger ReceptorCysteine Rich domain according to claim 1, wherein the protein comprisesthe amino acid sequence of SEQ ID NO:
 3. 3. A method of producing aprotein comprising a Scavenger Receptor Cysteine Rich domain, the methodcomprising culturing a transformant that expresses a protein comprisingthe amino acid sequence of SEQ ID NO:
 1. 4. A method of producing aprotein comprising a Scavenger Receptor Cysteine Rich domain, the methodcomprising culturing a transformant that expresses a protein comprisingthe amino acid sequence of SEQ ID NO:
 3. 5. The protein of claim 1,wherein the protein is a fusion protein comprising the ScavengerReceptor Cysteine Rich domain.
 6. The protein of claim 2, wherein theprotein is a fusion protein comprising the Scavenger Receptor CysteineRich domain.
 7. The protein of claim 1 consisting of the amino acidsequence of SEQ ID NO:
 1. 8. The polypeptide of claim 2 consisting ofthe amino acid sequence of SEQ ID NO:
 3. 9. A fusion protein comprisinga Scavenger Receptor Cysteine Rich domain, wherein the fusion protein isa product of a bacterial culture deposited with the Deutche Sammlung vonMikroorganismen und Zellkulturen under Accession No. DSM
 11281. 10. Apolypeptide comprising a Scavenger Receptor Cysteine Rich domainselected from the Scavenger Receptor Cysteine Rich domains of SEQ IDNOS: 1 or SEQ ID NO: 3, wherein the polypeptide binds to an antibodywhich also binds to a Scavenger Receptor Cysteine Rich domain of afusion protein, which is a product of a bacterial culture deposited withthe Deutche Sammlung von Mikroorganismen und Zellkulturen underAccession No. DSM
 11281. 11. A fusion protein comprising a ScavengerReceptor Cysteine Rich protein, which is a product of a bacterialculture deposited with the Deutche Sammlung von Mikroorganismen undZellkulturen under an Accession No. selected from the group consistingof: DSM 11280, DSM 11277, DSM 11278, DSM 11279, DSM 11646, DSM 11647,DSM 11648 and DSM
 11649. 12. The fusion protein of claim 11, wherein theScavenger Receptor Cysteine Rich protein is deposited under AccessionNo. DSM
 11280. 13. The fusion protein of claim 12, wherein the bacterialculture is deposited under Accession No. DSM
 11277. 14. The fusionprotein of claim 12, wherein the bacterial culture is deposited underAccession No. DSM
 11278. 15. The fusion protein of claim 12, wherein thebacterial culture is deposited under Accession No. DSM
 11279. 16. Thefusion protein of claim 12, wherein the bacterial culture is depositedunder Accession No. DSM
 11646. 17. The fusion protein of claim 12,wherein the bacterial culture is deposited under Accession No. DSM11647.
 18. The fusion protein of claim 12, wherein the bacterial cultureprotein is deposited under Accession No. DSM
 11648. 19. The fusionprotein of claim 12, wherein the bacterial culture is deposited underAccession No. DSM 11649.